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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
SPF-rats (Wistar TNO W 74, breeding: Winkelmann, Borchen)
Age: ca. 14 weeks
Average starting BW: 184 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
0.1; 0.5; 1.0; 1.1; 1.2; 1.3; 1.4 ml/kg
No. of animals per sex per dose:
10
Details on study design:
The rats were kept in a makrolon cage type III. 5 animals per cage. The animals were fed with Altromin R 1324 (Altromin GmbH, lage) and tap water ad libitum.
Statistics:
Probit-Analysis

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
1.003 mL/kg bw
Based on:
test mat.
95% CL:
>= 0.775 - <= 1.156

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The LD50 for acute oral toxicity is 1.00 ml/kg BW or based on a density of 1.408 g/ml 1.410 mg/kg BW