Lithium (C8-C10, branched, C9 rich, alkylnaphthalene sulphonate)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1981

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: limited report, non-GLP, no accurate determination of the exposure level. The information in the report is limited to the information in the summary.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: FHSLA, 16 CFR 1500

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Lithium (di C8-C10, branched, C9 rich, alkylnaphtalene sulphonate)

IUPAC Name:

Lithium (di C8-C10, branched, C9 rich, alkylnaphtalene sulphonate)

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Taconic Farm
- Age at study initiation: not indicated
- Weight at study initiation: males: 239-279 g ; females: 244-288 g
- Housing: individually
- Diet: Fisher Rat Chow ad libitum
- Water: ad libitum
- Acclimation period: 28 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

other: oil (not further defined0

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION: no data

TEST ATMOSPHERE: expected to be an aerosol

VEHICLE
- Composition of vehicle (if applicable): not indicated
- Concentration of test material in vehicle (if applicable): 33%

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

ca. 4.5 h

Concentrations:

10.4 mg/l iter/hour (5.2 as active)

No. of animals per sex per dose:

5 males + 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not indicated; body weights at start and end of the study
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Statistics:

NA

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 10.4 mg/L air (nominal)

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5.2 mg/L air (nominal)

Based on:

act. ingr.

Mortality:

none

Clinical signs:

other: none reported

Body weight:

within expected ranges in males, decreased in females

Gross pathology:

not performed

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LC50 of the test substance is > 5.2 mg/L

Executive summary:

Rats (5/sex) were exposed to the test substance at 5.2 mg/L by inhalation. No mortality or clinical signs were observed. Body weight gain in females was decreased over the 14 -day observation period. It is therefore concluded that the LC50 is >5.2 mg/L