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EC number: 611-173-2 | CAS number: 54605-02-6
Table 1: Tabular in vitro irritancy scores (IVIS)
Opacity per cornea
Permeability per cornea
IVIS per cornea
IVIS per group
(0.9 % NaCl)
(20 % Imidazole)
(20 % Bromhydrinvalerat)
No potential for serious eye damage was concluded from the study, as the IVIS was below 55 for the test item.
Bromhydrinvalerat was investigated in the Bovine Corneal Opacity and Permeability (BCOP) test according to OECD TG 437. The epithelial surface of the corneas was exposed to 750 µL of the test substance formulated in physiological saline. Measurement of corneal opacity and permeability after a 4 hours exposure followed by a post-treatment incubation of 90 minutes revealed an in vitro irritation score (IVIS) of 8.4, well below the threshold for classification of serious eye damage (IVIS <= 55). The positive (20 % imidazole) and vehicle (physiological saline solution) controls confirmed the validity of the test. Thus, under the conditions of this test bromhydrinvalerat was characterized by having no potential to seriously damage the eye.
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