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EC number: 611-173-2 | CAS number: 54605-02-6
Table 1: Number of dead animals per dose group after single oral application of difluocortolon-valerinat (ZK 22612) to rats:
After single oral administration of the test item difluocortolon-valerianat (diflucortolone-21-valerate) in doses of 2000, 2500, 3000, 3500 and 4000 mg/kg bw to male and female rats (5/sex/group) clinical signs (emaciation, ungroomed coat , apathy, sporadic increased girth of abdomen, individual anaemic animals) were observed starting at 2000 mg/kg bw. Mortality was observed at 2000 mg/kg bw and above in both sexes. Animals died between 5 and 22 days after application. At necropsy perforating ulcers in the cutaneous stomach mucosa were observed in sacrificed animals at the end of the observation period (from 2500 mg/kg bw). In animals found dead perforating ulcers in the cutaneous stomach mucosa and splenic athropy (from 2000 mg/kg bw), hyperemia in the gastrointestinal tract and necrobiosis in the liver (from 2500 mg/kg bw) as well as petechial bleedings in the glandular stomach mucosa and anaemic renal infarction (from 3000 mg/kg bw) were recorded. The acute oral toxicity (LD50) of diflucortolone-21-valerate was determined to be 3100 mg/kg bw for male and female rats.
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