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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
Principles of method if other than guideline:
In considersation of the relevance of granulometry on toxicological assessment, only the size distribution of the sieved fraction <100 µm were studied in detail.
GLP compliance:
no
Type of method:
sieving
Type of distribution:
mass based distribution
Test material information:
Composition 1
Specific details on test material used for the study:
- Purity not specified
- Batch Number: UN100EK
Mass median aerodynamic diameter:
34.27 µm
Key result
Percentile:
D50
Mean:
34.27 µm
Remarks on result:
other: spherical volume
No.:
#1
Size:
>= 10 - <= 100 µm
Distribution:
97.97 %
Remarks on result:
other: of the sieve fraction < 100 µm
No.:
#2
Size:
>= 4 - <= 10 µm
Distribution:
2.03 %
Remarks on result:
other: of the sieve fraction < 100µm

Result: Sieve Fraction (<100µm):

- weighted sample: 0.4704 g

- weight fraction <100 µm: 0.0672 g

- mass fraction <100 µm: 14.29 %

The mass fraction <100 µm was 14.29 %, and was investigated by scanning electron microscopy. The mean diameter (median) was 12.23 µm with 9.23 µm standard deviation. The median aspect ratio (median) was 1.77 with 0.60 as standard deviation.

The median diameter (mass fraction) of the particle size is given for the fraction <100 µm. The value 34.27 µm was calculated for spherical and the value 33.61 µm was calculated for cubical particles.

 Particle Size  Spherical Volume [%]  Cubical Volume [%]
 <4 µm (respirable)  0.00 0.00
 4-10 µm (thoracic)  2.03 2.63
 10-100 µm (inhalable)  97.97  97.37
 >100 µm 0.00 0.00
 Median (diameter µm) 34.27 33.61
Conclusions:
The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a value of 34.27 µm as spherical particles.
Executive summary:

According to OECD guideline 110 the particle size distribution of bromhydrin-valerat was determined by scanning electron microscopy method for the sieved fraction (<100 µm was 14.29 % of the total sample) and presented on the basis of calculated mass fractions.

The mean diameter (median) was 12.23 µm with 9.23 µm standard deviation. The median aspect ratio (median) was 1.77 with 0.60 as standard deviation. The median diameter (mass fraction) of the particle size is given for the fraction <100 µm. The value 34.27 µm was calculated for spherical particles and hence the tested particles with sieved size smaller than 100 µm are mainly dominated by inhalable fraction as defined in EN 481.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a value of 34.27 µm as spherical particles.

Additional information

According to OECD guideline 110 the particle size distribution was determined by scanning electron microscopy method for the sieved fraction (< 100 µm, 14.29 % of total sample) and presented on the basis of calculated mass fractions. The median diameter was 34.27 µm with the main fraction of 97.97 % spherical volume distributing in the range of 10 -100 µm and hence the tested particles with sieved size smaller than 100 µm are mainly dominated by inhalable fraction as defined in EU 481. Accounting based on the total sample weight the spherical volume was 14 %.