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EC number: 931-295-2 | CAS number: -
* Examinations were performed at the specified times after removal of the dressing.
n.a. = not assessable due to necrosis produced by the test item.
† = no observation point (animal was killed on test day 2)
Skin Irritation Scores - Mean Values after 24, 48 and 72 Hours
Not applicable. Since one animal was killed after the 24-hour observation point (female) and one
animal after the 48-hour observation point (male), mean scores could not be assessed.
Skin Irritation Scores - Assessment According to EC Classification Guidelines
3 min (91, M)
1h, 24h, 48h
4 hours (92, F)
Body weights (g):
The primary skin irritation potential of Alkoxypropandiamineacetate and alkoxypropandiamine was investigated according to OECD test guideline No. 404 and Commission Regulation (EC) No. 440/2008, B.4. The test item was applied by topical semi-occlusive application of 0.5 mL to the intact left flank of two adult New Zealand White rabbits. The duration of treatment was four hours (for one female, by mistake) or three minutes (for one male). The scoring of skin reactions was performed 1 and 24 hours (female) or 1, 24 and 48 hours after removal of the dressing.
The mean score could not be calculated across 3 relevant scoring times (24, 48 and 72 hours after patch removal, according to the guidelines) since the animals were killed due to ethical reasons either on test day 2 (female) or 3 (male).
The application of Alkoxypropandiamineacetate and alkoxypropandiamine to the skin resulted in severe erythema and oedema and depigmentation of the treated skin (blanching) one hour after the 4-hour application period (female). At the 24-hour observation point, the entire treated skin area was necrotic and the animal was killed for ethical reasons. Then, the application period was shortened to 3 minutes (male). Well-defined erythema, slight oedema and blanching were noted one hour after removal of the dressing. However, at the 24-hour observation point, the treated skin area evolved a necrosis, which persisted until the 48-hour observation point when this animal was also killed for ethical reasons. For both animals teated, no clinical signs were recorded throughout the observation period.
Thus, the test item induced irreversible damage to the skin.
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