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EC number: 931-295-2
CAS number: -
A study was performed, according to OECD 401
and under GLP, to determine the acute oral median lethal dose (LD50) of
the test material, administered as a solution in arachis oil B.P. in the
Sprague-Dawley strain rat . In a range-finding study (2000, 200 and 25
mg/kg bw, 2 animals sex dose) all animals were found dead the next day
at 2000 mg/kg bw and one animal died at 200 mg/kg bw at day 4. Following
these results a group of ten fasted animals (five males and five
females) was given a single oral dose of test material preparation at a
dose level of 200 mg/kg bodyweight. There were no deaths. Signs of
toxicity were confined to hunched posture and pilo-erection observed 4
hrs after dosing in all animals and on day one in one male. All animals
showed expected gain in bodyweight during the study period. No
abnormalities were noted at necropsy of animals killed at the end of the
study . The acute oral median lethal dose (LD50) o f the test material,
LILAFLOT D817, to the Sprague-Dawley strain rat was found to be greater
than 200 mg/kg but less than 2000 mg/kg bodyweight. Formal
classification under GHS is not possible, but LD50 is expected >= 300
mg/kg, using a LD50 cut-off level of 500 mg/kgbw seems appropriate.
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