Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact the toxicity potential. Source study has reliability 4: only limited information available from a migrated NONS file, as per Article 25(3) request.

Data source

Reference
Reference Type:
other: information from migrated NONS file, as per Article 25(3) request, permission to refer granted by ECHA
Title:
Unnamed
Year:
1985

Materials and methods

Principles of method if other than guideline:
No information on the method is available.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Similar substance 01
IUPAC Name:
Similar substance 01
Test material form:
solid

Administration / exposure

Duration of treatment / exposure:
28 days

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
ca. 1 000 mg/kg bw/day (nominal)
Based on:
not specified
Sex:
not specified
Basis for effect level:
other: not specified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
NOAEL = ca. 1000 mg/kg bw/day
Executive summary:

Method

No information on the method is available. Information derived from migrated NONS file, as per Article 25(3) request, permission to refer granted by ECHA.

 

Results

NOAEL = ca. 1000 mg/kg bw.