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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
2. no data available
3. Structure estimation method
Duration:
5 d
Temp.:
25 °C
Remarks:
2. The study was performed at pH 4, 7 and 9, respectively.
Remarks:
3. Details not known
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Temp.:
25 °C
DT50:
> 5 d
Remarks on result:
other: 2. Although the exact half-life value of test chemical was not known, but was reported to be stable during a period of 5 days. The study was performed at pH 4, 7 and 9, respectively.
pH:
7
DT50:
1.4 yr
Type:
second order
Remarks on result:
other: 3. Hydrolysis rate constant is 0.16 L/mol-sec.
pH:
8
DT50:
51 d
Type:
second order
Remarks on result:
other: 3. Hydrolysis rate constant is 0.16 L/mol-sec.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to undergoe > 5 days to 1.4 yrs at a pH range 4-9, respectively & at a temperature of 25⁰C. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life of the test chemicalwas determined at different pH range.The study was performed according toOECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH 4, 7 and 9, respectively. Although the exact half-life value of test chemical was not known, but was reported to be stable during a period of 5 days.Thus, the half-life value of test chemical can be determined to be > 5 daysat a pH 4, 7 and 9 & at a temperature of25⁰C, respectively, indicating that the test chemical is not hydrolysable.

In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to undergoe > 5 days to 1.4 yrs at a pH range 4-9, respectively & at a temperature of 25⁰C. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to undergoe > 5 days to 1.4 yrs at a pH range 4-9, respectively & at a temperature of 25⁰C. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.

Key value for chemical safety assessment

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH 4, 7 and 9, respectively. Although the exact half-life value of test chemical was not known, but was reported to be stable during a period of 5 days. Thus, the half-life value of test chemical can be determined to be > 5 days at a pH 4, 7 and 9 & at a temperature of25⁰C, respectively, indicating that the test chemical is not hydrolysable.

 

In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to undergoe > 5 days to 1.4 yrs at a pH range 4-9, respectively & at a temperature of 25⁰C. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.