Registration Dossier
Registration Dossier
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EC number: 253-973-0 | CAS number: 38495-30-6
Endpoint summary
Administrative data
Description of key information
In a study conducted according to OECD TG 401 and in compliance with GLP, the acute oral LD50 for rats was determined to be >2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
12,12-dimethyl-2,5,8,11,13,16,19,22-octaoxa-12-silatricosane was tested in an acute oral toxicity study in rats, in accordance with OECD TG 401 and in compliance with GLP. 5 males and 5 females were administered a single oral dose of 2000 mg/kg bw undiluted test material by gavage. There were no mortalities or adverse necropsy findings and no effects on body weight gain over the 14-day observation period. Clinical signs included hunched posture, pilo-erection and decreased respiratory rate in all treated animals at 1 and 4 hours post-administration. Additionally, lethargy was noted in 5 out of 10 animals, as well as ataxia in 4 out of 10 animals at 1 and 4 hours after dosing. Ptosis was also observed in 2 out of 10 animals at 1 hour post-treatment. All animals recovered and appeared normal on day 1 after administration.
Justification for selection of acute toxicity – oral endpoint
The selected study is the only study available for this endpoint. The test was conducted according to an appropriate OECD test guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available acute oral toxicity study, the substance is not classified for acute toxicity according to Regulation (EC) No. 1272/2008.
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