2-octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: data from modelling database

Qualifier:

equivalent or similar to guideline

Guideline:

other: predicted data

Principles of method if other than guideline:

BCFBAF Program (v3.01)

GLP compliance:

not specified

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
estimated data

Radiolabelling:

not specified

Details on sampling:

estimated data

Vehicle:

not specified

Details on preparation of test solutions, spiked fish food or sediment:

estimated data

Test organisms (species):

other: fish

Details on test organisms:

estimated data

Route of exposure:

aqueous

Test type:

static

Water / sediment media type:

not specified

Remarks:

freshwater

pH:

estimated data

Dissolved oxygen:

estimated data

TOC:

estimated data

Salinity:

estimated data

Details on test conditions:

estimated data

Nominal and measured concentrations:

estimated data

Type:

BCF

Value:

18.09 L/kg

Basis:

other: estimated data

Calculation basis:

other: estimated data

Remarks on result:

other: Log BCF (regression-based estimate): 1.257 (BCF = 18.09 L/kg wet-wt)

BCFBAF v3.01

Log BCF (regression-based estimate): 1.26 (BCF = 18.1 L/kg wet-wt)

Biotransformation Half-Life (days) : 162 (normalized to 10 g fish)

Log BAF (Arnot-Gobas upper trophic): 2.01 (BAF = 101 L/kg wet-wt)

Log Kow (experimental): not available from database

Log Kow used by BCF estimates: 12.85

Equation Used to Make BCF estimate:

Log BCF = -0.49 log Kow + 7.554 + Correction

Correction(s): Value

No Applicable Correction Factors

Estimated Log BCF = 1.257 (BCF = 18.09 L/kg wet-wt)

Validity criteria fulfilled:

not specified

Conclusions:

The estimated BCF value for 2 Octadecyl1Hthioxantheno(2,1,9def)isoquinoline1,3(2H)dione in fish was 18.09 L/kg

Executive summary:

Bioaccumulation potential of2 Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione was estimated by BCFBAF v3.01 Program from EPISuite Version 4.1.

BCFBAF v3.01

Log BCF (regression-based estimate): 1.26 (BCF = 18.1 L/kg wet-wt)

Biotransformation Half-Life (days) : 162 (normalized to 10 g fish)

Log BAF (Arnot-Gobas upper trophic): 2.01 (BAF = 101 L/kg wet-wt)

Log Kow (experimental): not available from database

Log Kow used by BCF estimates: 12.85

Equation Used to Make BCF estimate:

Log BCF = -0.49 log Kow + 7.554 + Correction

Correction(s): Value                                                          

No Applicable Correction Factors

Estimated Log BCF = 1.257 (BCF = 18.09 L/kg wet-wt)

The estimated BCF value for 2 Octadecyl-1H-thioxantheno (2,1,9-def)isoquinoline-1,3(2H)-dione in fish was 18.09 L/kg

Based on the classification criterion for PBT,2 Octadecyl -1H-thioxantheno (2,1,9-def)isoquinoline-1,3(2H)-dione can be considered to be non- bioaccumulative in nature.

Description of key information

The estimated BCF value for 2 Octadecyl1Hthioxantheno(2,1,9def)isoquinoline1,3(2H)dione  in fish was 18.09 L/kg

Key value for chemical safety assessment

BCF (aquatic species):

18.09 L/kg ww

Additional information

Bioaccumulation potential of 2 Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione was estimated by BCFBAF v3.01 Program from EPISuite Version 4.11. The estimated BCF value for 2 Octadecyl-1H-thioxantheno (2,1,9-def)isoquinoline-1,3(2H)-dione in fish was 18.09 L/kg .

Based on the classification criterion for PBT, 2 Octadecyl -1H-thioxantheno (2,1,9-def)isoquinoline-1,3(2H)-dione can be considered to be non- bioaccumulative in nature.