Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(4aR,4bS,6aS,9aS,9bR,11aR)-4a,6a-Dimethyltetradecahydro-1H-indeno[5,4-f]quinoline-2,7-dione
EC Number:
616-323-0
Cas Number:
76318-69-9
Molecular formula:
C18H27NO2
IUPAC Name:
(4aR,4bS,6aS,9aS,9bR,11aR)-4a,6a-Dimethyltetradecahydro-1H-indeno[5,4-f]quinoline-2,7-dione

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
5.66 mg/L
Nominal / measured:
estimated
Remarks on result:
other: QSAR VegaNIC (EPA)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
9.76 mg/L
Nominal / measured:
estimated
Remarks on result:
other: QSAR T.E.S.T. (HCM)

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: VegaNIC, T.E.S.T., the predicted values indicated that finasteride saturated lactam is hazardous to the fishes. The result meets the requirement of Aquatic Acute Category 2.