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Diss Factsheets

Physical & Chemical properties

Density

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Reference
Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 1994 - February 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Deviations:
no
GLP compliance:
yes
Type of method:
air comparison pycnometer (for solids)
Key result
Type:
density
Density:
1.298 other: g/ml
Temp.:
20 °C
Remarks on result:
other: ± 1 ºC
Key result
Type:
relative density
Density:
1.298 g/cm³
Temp.:
20 °C
Remarks on result:
other: ± 1 ºC

Table 1. Test substance density measurements.

Sample weight (g)

Sample volume (ml)*

Density (g/ml)

15.5545

11.97

1.299

11.4215

8.81

1.297

Mean Value

1.298

*Mean value of 5 determinations.

Conclusions:
Density at 20 ºC: 1.298 g/ml.
Executive summary:

The study followed the EU Method A.3, gas comparison pycnometer method.

The density of Fosfomycin PEA salt at 20 ± 1 ºC is 1.298 g/ml.

Description of key information

Key study: Test method according to EU Method A.3. GLP study.

Key value for chemical safety assessment

Relative density at 20C:
1.298

Additional information

Key study: Test method according to EU Method A.3, gas comparison pycnometer method. GLP study. The density of Fosfomycin PEA salt at 20 ± 1 ºC is 1.298 g/ml.