Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-643-7 | CAS number: 109-06-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental study by a reputable industry laboratory, prior to establishment of international guidelines and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day.
- GLP compliance:
- no
- Type of study:
- other: guinea pig
Test material
- Reference substance name:
- Pyridine
- EC Number:
- 203-809-9
- EC Name:
- Pyridine
- Cas Number:
- 110-86-1
- Molecular formula:
- C5H5N
- IUPAC Name:
- pyridine
- Details on test material:
- no data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Concentration / amount:
- no data
Challengeopen allclose all
- Route:
- other: likely dermal
- Concentration / amount:
- no data
- No. of animals per dose:
- no data
- Details on study design:
- no data provided in this summary
Results and discussion
In vivo (non-LLNA)
Results
- Clinical observations:
- Not sensitising
- Remarks on result:
- other: Clinical observations: Not sensitising.
Any other information on results incl. tables
Not sensitising in guinea pigs.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Alpha picoline (2-methylpyridine) is a member of a chemical category including pyridine and pyridine derivatives. The dermal sensitisation properties of pyridine were studied in the guinea pig, and pyridine was found to be a non-sensitiser. Reading-across from pyridine to this substance is valid for the purposes of classification and risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
