Registration Dossier
Registration Dossier
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EC number: 262-038-6 | CAS number: 60047-17-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The test is not conducted under the GLP and it has been performed prior to the current OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test has been performed prior to the current OECD guideline.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol
- EC Number:
- 262-038-6
- EC Name:
- 2-(tetrahydro-5-methyl-5-vinyl-2-furyl)propan-2-ol
- Cas Number:
- 60047-17-8
- Molecular formula:
- C10H18O2
- IUPAC Name:
- 2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propan-2-ol
- Test material form:
- other: liquid
- Details on test material:
- Sample marking 77-288, Linalool Oxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: no data available
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- Oral gavage.
- Doses:
- 0.60 ; 0.85 ; 1.22 ; 1.73 ; 5.0 g/Kg
- No. of animals per sex per dose:
- 10 animals tested (1dose/ animal)
- Control animals:
- no
- Details on study design:
- Personnel communication as a high level one page document.
Results and discussion
- Preliminary study:
- NA
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1.15 other: g/Kg
- Based on:
- test mat.
- 95% CL:
- > 0.9 - < 1.74
- Mortality:
- 2 animals died at 0.85 g/Kg
7 animals died at 1.22 g/Kg
10 animals died at 1.73 g/Kg
10 animals died at 5 g/Kg - Clinical signs:
- other: Deaths.
- Gross pathology:
- NA
- Other findings:
- NA
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Acute Oral Category 4 Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 Oral has been determined to be LD50= 1'150 mg/Kg under the test conditions.
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