Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP compliant study conducted according to OECD Guidelines, with no or minor deviations.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(E)-4-decenal
EC Number:
265-741-6
EC Name:
(E)-4-decenal
Cas Number:
65405-70-1
Molecular formula:
C10H18O
IUPAC Name:
(E)-4-decenal
Test material form:
other: pale yellow liquid
Details on test material:
Batch number: 256181
Purity : 96.7%
Expiry date : October 10, 1997

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
1 male
2 females

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 mL (per animal) applied
Duration of treatment / exposure:
4 hours
Observation period:
1h, 24h, 48h, 72 hours and 7 days, 14 days, 21 days
Number of animals:
1 male
2 females

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: 7
Time point:
other: mean value 24, 48 and 72 hours
Score:
0
Max. score:
0
Remarks on result:
other: male
Irritation parameter:
erythema score
Basis:
animal: 8
Time point:
other: mean value 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 14 days
Remarks on result:
other: female
Irritation parameter:
erythema score
Basis:
animal: 9
Time point:
other: mean value 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: female
Irritation parameter:
edema score
Basis:
animal: 7
Time point:
other: mean value 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 14 days
Remarks on result:
other: male
Irritation parameter:
edema score
Basis:
animal: 8
Time point:
other: mean value 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 14 days
Remarks on result:
other: female
Irritation parameter:
edema score
Basis:
animal: 9
Time point:
other: mean value 24, 48 and 72 hours
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: female

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: EU GHS
Conclusions:
According to this test the DECENAL-4-TRANS is slightly irritant. However based on the scores, it is not sufficient to be classified irritant accroding the EU GHS.