Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 3,7,11-trimethyldodecyn-3-ol, CAS: 1604-35-9
- Physical state:
- Analytical purity: 98.8 area-%
- Impurities (identity and concentrations):
- Purity test date:
- Lot/batch No.:
- Stability under test conditions:
- Storage condition of test material:
- Other:

Test animals / tissue source

Species:
rabbit

Test system

Amount / concentration applied:
undiluted
Amount applied: 0.1 ml
Duration of treatment / exposure:
24 hour(s)
Number of animals or in vitro replicates:
3
Details on study design:
Comment: rinsed after (see exposure time)

Results and discussion

Any other information on results incl. tables

RS-Freetext:
The ocular reactions were assessed approximately 1, 24, 48 and 72 hours after application.
Slight or moderate conjunctival redness, moderate or severe discharge and injected scleral vessels in a circumscribed area were observed in the animals within 24 hours after
application.
The ocular reactions were reversible in all animals within 48 hours after application at latest.
The average score (24 to 72 hours) for irritation was calculated to be 0.0 for corneal opacity, iris and chemosis and 0.1 for conjunctival redness

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
Classification: not irritating