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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
p-anisidine
EC Number:
203-254-2
EC Name:
p-anisidine
Cas Number:
104-94-9
Molecular formula:
C7H9NO
IUPAC Name:
4-methoxyaniline
Details on test material:
- Name of test material (as cited in study report): p-Anisidine
- Molecular formula : C7-H9-N-O
- Molecular weight: 123.1541g/mol
- Smiles notation: c1(ccc(cc1)N)OC
- InChl: 1S/C7H9NO/c1-9-7-4-2-6(8)3-5-7/h2-5H,8H2,1H3
- Substance type: Organic
- Physical state: Grey to brown crystalline powder

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes

Test organisms

Test organisms (species):
Oryzias latipes
Details on test organisms:
- Common name: Japanese killifish

Study design

Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
96 h

Test conditions

Test temperature:
24±1 degree C
Nominal and measured concentrations:
0 (control), 100 mg/L
Details on test conditions:
TEST SYSTEM
- Material, size, headspace, fill volume: test liquid volume 2.5 L per vessel
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): every 48 hours
- No. of organisms per vessel: 10 per concentration
- No. of vessels per concentration (replicates): 2

OTHER TEST CONDITIONS
- Photoperiod: 16 hours light - 8 hours dark

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)

Applicant's summary and conclusion

Conclusions:
LC50 value for p-Anisidine in Oryzias latipes when exposed for 96 h was found to be >100 mg/L.
Executive summary:

In a study short term toxicity to fish for p-Anisidine in Oryzias latipes when it was exposed for 96 h under semi-static condition. Mortality were not observed at concentration of 100 mg/l.

Therefore LC50 was considered to be >100 mg/l for p-Anisidine in Oryzias latipes when exposed for 96 h under semi-static condition.