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EC number: 202-311-9 | CAS number: 94-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral toxicity studies were carried out to estimate the toxicity of Tridecanol
In the acute oral study conducted in Carworth - Wistar rats, the acute oral LD50 (with± 1.96 standard deviations) for tridecyl alcohol was found to be 2290.4 mg/kg (17.2ml/kg) ( range 16383.6 - 31834.8 mg/kg (12.3 – 23.9ml/kg)).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from study report
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity test was performed on mice by oral route
- GLP compliance:
- no
- Test type:
- other: No data
- Species:
- rat
- Strain:
- other: Carworth -Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: No data
Age at study initiation: 4 -5 weeks
Weight at study initiation: 90 -120g
Fasting period before study: No fasting
Housing: No data
Diet (e.g. ad libitum): weaning Rockland rat diet
Water (e.g. ad libitum): No data - Route of administration:
- oral: gavage
- Vehicle:
- other: gastric intubation of either the undiluted material or a solution in water or corn oil or as an agar suspension.
- Details on oral exposure:
- VEHICLE
Concentration in vehicle: No data
Amount of vehicle (if gavage): No data
Justification for choice of vehicle: No data
Lot/batch no. (if required): No data
Purity: No data
MAXIMUM DOSE VOLUME APPLIED:
No data
DOSAGE PREPARATION (if unusual): No data
CLASS METHOD (if applicable)
Rationale for the selection of the starting dose:
Doses were given in a logarithmic series differing by a factor of 2. - Doses:
- Doses were given in a logarithmic series differing by a factor of 2.
- No. of animals per sex per dose:
- Groups of 5 male rats
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days (or other?): 14 days
Frequency of observations and weighing: No data
Necropsy of survivors performed: yes/no: No data - Statistics:
- The most probable LD50 value and its fiducial range are estimated by the method of Thompson, using the Tables of Weil. The figures in parentheses show limits of ± 1.96 standard deviations while the absence of parentheses indicates that no range is calculable because no dosage resulted in fractional mortality
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 22 910.4 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were observe
- Clinical signs:
- other: To toxic effect was observe
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute Oral toxicity studies were carried out to estimate the toxicity of Tridecanol
In the acute oral study conducted in Carworth - Wistar rats, the acute oral LD50 (with± 1.96 standard deviations) for tridecyl alcohol was found to be 2290.4 mg/kg (17.2ml/kg) ( range 16383.6 - 31834.8 mg/kg (12.3 – 23.9ml/kg)). - Executive summary:
Acute Oral toxicity studies were carried out to estimate the toxicity of Tridecanol
Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, four to five weeks of age and 90 to120 grams in weight which have been reared in our own colony and maintained from time of weaning on Rockland rat diet, complete.The dosages are arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical is administered undiluted form.The most probable LD50 value and its fiducial range are estimated by the method of Thompson, using the Tables of Weil. The figures in parentheses show limits of ± 1.96 standard deviations while the absence of parentheses indicates that no range is calculable because no dosage resulted in fractional mortality
In the acute oral study conducted in Carworth - Wistar rats, the acute oral LD50(with± 1.96 standard deviations)for tridecyl alcohol was found to be 2290.4 mg/kg (17.2ml/kg) ( range 16383.6 - 31834.8 mg/kg (12.3 – 23.9ml/kg)).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 290.4 mg/kg bw
- Quality of whole database:
- Data is from peer reviewed journal
Additional information
Acute toxicity: oral
Various studies were reviewed and the effect of the test compound onacute oral toixicty. These are summarized as follows:
Single oral dose (Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel, 1962) toxicity is estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, four to five weeks of age and 90 to120 grams in weight which have been reared in our own colony and maintained from time of weaning on Rockland rat diet, complete.The dosages are arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical is administered undiluted form.The most probable LD50 value and its fiducial range are estimated by the method of Thompson, using the Tables of Weil. The figures in parentheses show limits of ± 1.96 standard deviations while the absence of parentheses indicates that no range is calculable because no dosage resulted in fractional mortality In the acute oral study conducted in Carworth - Wistar rats, the acute oral LD50(with± 1.96 standard deviations)for tridecyl alcohol was found to be 2290.4 mg/kg (17.2ml/kg) ( range 16383.6 - 31834.8 mg/kg (12.3 – 23.9ml/kg)).
From peer reviewed journal, Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice, 1985.Acute toxicity test was performed on 10 mice at 2% concentration for 5 days test of repellency. After test it was found that the repellency percentage for house mouse toBenzylparaben(94-18-8) was found to be 10 %.
From study report, Final Amended Report on the Safety Assessment Methylparraben, Ethylparaben, Propylparaben, lsopropylparaben, Butylparaben, lsobutylparaben and Benzylparaben as used in Cosmetic Products, 2008. Acute oral toxicity test was performed on guinea pig at 2000 mg concentration of benzylparaben given by oral route. No injurious effects were observed after treatment.
Therefore, the LD 0 value for benzylparaben (94-18-8) was found to be 2000 mg concentration.
Also from the same study report the Acute oral toxicity test was performed on guinea pig at 5000 mg concentration of benzylparaben given by oral route. No injurious effects were observed after treatment.
Therefore, the LD 0 value for benzylparaben (94-18-8) was found to be 5000 mg concentration.
Acute oral toxicity test was performed on mice at 10000 mg/kg concentration of benzylparaben given by oral route. No death and toxic effects were observed after treatment.Therefore, the LD 0 value for benzylparaben (94-18-8) was found to be 10000 mg/kg concentration.
From above mentioned supporting studies the target chemical benzylparaben (CAS No 94-18-8), the majority values are indicative that the chemical is likely to causeaquaticmicroorganisms.
Justification for selection of acute toxicity – oral endpoint
Acute Oral toxicity studies were carried out to estimate the toxicity of Tridecanol
In the acute oral study conducted in Carworth - Wistar rats, the acute oral LD50 (with± 1.96 standard deviations) for tridecyl alcohol was found to be 2290.4 mg/kg (17.2ml/kg) ( range 16383.6 - 31834.8 mg/kg (12.3 – 23.9ml/kg)).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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