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EC number: 202-658-6 | CAS number: 98-33-9
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment:
From BCFBAF Program (v3.00) model of EPI suite the estimated bio concentration factor (BCF) for 4-amino-3-methylbenzenesulfonic acid is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000 (as per the CLP regulation).Thus it is concluded that chemical 4-amino-3-methylbenzenesulfonic acid is not expected to be bioaccumulative in fish and the food chain.
Additional information
Bioaccumulation: aquatic / sediment:
Four different studies including those from validated prediction databases and experimental study for bioaccumulation endpoint of target chemical 4-amino-3-methylbenzenesulfonic acid (Cas no. 98-33-9)and relevant read across which is structurally similar to target chemical are summarized as followed:
First study from prediction report by BCFBAF (v3.00) model of EPI Suite program indicated the estimated bio concentration factor (BCF) for 4-amino-3-methylbenzenesulfonic acid as 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.
And predicted database PBT profiler propose the Bioaccumulation factor (BCF) was predicted to be 3.2 L/kg wet-wt at 25 deg.C for test chemical 4-amino-3-methylbenzenesulfonic acid.
Above both studies are supported by another reliable predicted data sources i.e Chemspider - ACD/PhysChem Suite and Scifinder database which indicate the Bioconcentration factor (BCF) for target chemical 4-amino-3-methylbenzenesulfonic acid was predicted to be 1 at pH 1-10 and temperature 25 deg.C.
Finally an experimental study of read across chemical 4-amino-3-methylbenzenesulfonic acid (Cas no.121-57-3) give assistance to all predicted results of target substance which suggest Bioaccumulation test was conducted for 28 days for determination the bioconcentration factor (BCF) and lipid content of substance 4-aminobenzenesulfonic acid (Cas no.121-57-3) on test organism Cyprinus carpio. The recovery ratio is given- Fish: 87.5 % and Nominal concentrations used in the study as - 1st concentration area: 1 mg/L, 2nd concentration area: 0.1 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) and the 96 hr LC50 value was found to be 270 mg/L.By analytical methods, the limit of quantification was found to be- Test water: (Fish: 340 ng/g) ;1st concentration area: 31 µg/l and 2nd concentration area: 3.1µg/l .Whereas the lipid content at the start and end of exposure was found to be 2.14% and 2.05%, respectively. Thus according to guideline OECD Guideline 305 (Bioconcentration: Flow through Fish Test) the BCF value for test substance 4-aminobenzenesulfonic acid (Cas no.121-57-3) was observed to be <= 0.34 L/kg at dose concentration 1 mg/L and <= 3.5 L/kg at dose concentration 0.1 mg/L on test organism Cyprinus carpio during 28 day period. These values indicate that the substance is not bioaccumulative in fish and food chain. (J-check database;2017)
All values for bioaccumulation is in the range of <=0.34 -3.5 (L/kg or dimensionless) conclude that the target chemical 4-amino-3-methylbenzenesulfonic acid (Cas no. 98-33-9) isnot expected to be bioaccumulative in fish and the food chain.
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