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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed article or handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
SCREENING-LEVEL HAZARD CHARACTERIZATION Chloronitrobenzenes Category
Author:
U.S. Environmental Protection Agency
Year:
2012
Bibliographic source:
U.S. Environmental Protection Agency Hazard Characterization Document

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study was conducted to test the effects of m-chlorobenzene on rats and animals were observed for 14 days .Based on mortality the LD50 was determined.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-3-nitrobenzene
EC Number:
204-496-1
EC Name:
1-chloro-3-nitrobenzene
Cas Number:
121-73-3
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-3-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): 1-chloro-3-nitrobenzene
- Molecular formula (if other than submission substance): C6H4ClNO2
- Molecular weight (if other than submission substance): 165.191 g/mol
- Substance type: Solid
- Physical state: Organic
- Impurities (identity and concentrations): No data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
14 days
Doses:
0, 200, 251, 316, 398 or 501 mg/kg
No. of animals per sex per dose:
5/sex/dose
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
400 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mortalities were observed at 251, 316, 398 and 501 mg/kg.
Mortality:
Mortalities were observed at 251, 316, 398 and 501 mg/kg.
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was found to be 400mg/kg.
Test substance may be classified as acute toxicity catagory-4.
Executive summary:

Acute study is conducted to study the effect of the test substance onSprague-Dawley rats administered through gavage. The dose concentrations used were 0, 200, 251, 316, 398 or 501 mg/kg. Mortality was observed at 251, 316, 398 and 501 mg/kg.

The LD50was found to be 400mg/kg.