1-chloro-3-nitrobenzene

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Data is from authorative database

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

24hr short term toxicity studies was carried out to test the effects of 1 chloro-3-nitrobenzene.

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
No data available

Analytical monitoring:

not specified

Details on sampling:

Details on sampling
- Concentrations: 18.8mg/l

Vehicle:

not specified

Details on test solutions:

No data available

Test organisms (species):

Pimephales promelas

Details on test organisms:

TEST ORGANISM
- Common name: Fathead minnow
- Age at study initiation (mean and range, SD): 33 d
- Length at study initiation (length definition, mean, range and SD): Individual lengths and weigNAs of the test fish were not recorded.
- Weight at study initiation (mean and range, SD): the calculated mean weight was 0.148 g.

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

96 h

Post exposure observation period:

No data available

Hardness:

45.3

Test temperature:

23.0 deg. C

pH:

7.5

Dissolved oxygen:

7.0mg/l

Salinity:

Alkalinity: 42.8mg/l

Nominal and measured concentrations:

No data available

Details on test conditions:

No data available

Reference substance (positive control):

not specified

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

18.8 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Details on results:

- Behavioural abnormalities: Affected fish lost schooling behavior, were hypoactive, NR and lost equilibrium
prior to death.

Results with reference substance (positive control):

No data available

Reported statistics and error estimates:

No data available

Validity criteria fulfilled:

not specified

Conclusions:

Based on mortality the 96hr LC50 was determined to be 18.8mg/l for fathead minnow.
Based on the LC50 value the substance may be classified as aquatic chronic-3.

Executive summary:

Short term toxicity study have been carried out to test the effects of 1 Chloro-3-nitrobenzene on fresh water fish fathead minnow for 96hr.

Based on mortality the 96hr LC50 was determined to be 18.8mg/l for fathead minnow.

Description of key information

Based on mortality the 96hr LC50 was determined to be 18.8 mg/l for fathead minnow.Based on the LC50 value the substance may be classified as aquatic chronic-3.  

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

18.8 mg/L

Additional information

To evaluate toxicity to fish, various experimental studies were performed.Based on the experimental data aquired from various sources following is the discription:

Short term toxicity study have been carried out to test the effects of 1-Chloro-3-nitrobenzene on fresh water fish fathead minnow for 96hr.Based on mortality the 96 hr LC50 was determined to be 18.8 mg/l for fathead minnow.

in another supporting study,Short term toxicity study have been carried out to test the effects of 1-Chloro-3-nitrobenzene on fresh water fish fathead minnow for 24hr.Based on mortality the 24hr LC50 was determined to be 18 mg/l for fathead minnow.

Even though varied results for short term toxicity to fish were available but, based on the effect concentration from both the experimental study report,we can consider that the test chemical is toxic and can be classified as aquatic chronic 3.