Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monographs on fragrance materials
Author:
Opdyke, D. L. J.
Year:
1975
Bibliographic source:
Food and Cosmet. Toxicol., 13, 791, 1975
Reference Type:
secondary source
Title:
Opinion on Methyl-N-methylanthranilate (Phototoxicity only)
Author:
Scientific Committee on Consumer Safety
Year:
2011
Bibliographic source:
European Commission, Scientific Committee on Consumer Safety, 2011

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute inhalation toxicity study of Dimethyl Anthranilate in larvae
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl N-methylanthranilate
EC Number:
201-642-6
EC Name:
Methyl N-methylanthranilate
Cas Number:
85-91-6
Molecular formula:
C9H11NO2
IUPAC Name:
methyl 2-(methylamino)benzoate
Details on test material:
- Name of test material (as cited in study report): Dimethyl Anthranilate
- Molecular formula (if other than submission substance): C9H11NO2
- Molecular weight (if other than submission substance): 165.191 g/mole
- Substance type: Organic

Test animals

Species:
other: Tribolium destructor
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
not specified
Details on inhalation exposure:
No data available
Analytical verification of test atmosphere concentrations:
not specified
Concentrations:
115.1 mg/L
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
115.1 mg/L air
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality observed in exposed larvae of Tribolium destructor.
Clinical signs:
other: No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Conclusions:
LC50 was considered to be 115.1 mg/L when larvae of Tribolium destructor inhaled by Dimethyl Anthranilate
Executive summary:

In a acute inhalation toxicity study,larvae of Tribolium destructor were inhaled by Dimethyl Anthranilate in the concentration of 115.1 mg/L.50 % mortality was observed in exposed larvae of Tribolium destructor at115.1 mg/L. Therefore, LC50 was considered to be115.1 mg/L when larvae ofTribolium destructor inhaled by Dimethyl Anthranilate.