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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from EPI Suite modelling database
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
BCFBAF Program (v3.01)
GLP compliance:
no
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
not specified
Type:
BCF
Value:
33.3 L/kg
Basis:
whole body w.w.
Calculation basis:
other: estimated

BCFBAF Program (v3.01) Results:

==============================

SMILES : O=C(OC)c(c(NC)ccc1)c1

CHEM : Benzoic acid, 2-(methylamino)-, methyl ester

MOL FOR: C9 H11 N1 O2

MOL WT : 165.19

--------------------------------- BCFBAF v3.01 --------------------------------

Summary Results:

Log BCF (regression-based estimate): 1.52 (BCF = 33.3 L/kg wet-wt)

Biotransformation Half-Life (days) : 0.096 (normalized to 10 g fish)

Log BAF (Arnot-Gobas upper trophic): 1.39 (BAF = 24.4 L/kg wet-wt)

Log Kow (experimental): not available from database

Log Kow used by BCF estimates: 2.81

Equation Used to Make BCF estimate:

Log BCF = 0.6598 log Kow - 0.333 + Correction

Correction(s): Value

No Applicable Correction Factors

Estimated Log BCF = 1.522 (BCF = 33.3 L/kg wet-wt)

Conclusions:
The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
Executive summary:

The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.

Description of key information

The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.

Key value for chemical safety assessment

BCF (aquatic species):
33.3 L/kg ww

Additional information

The estimated bioconcentration factor (BCF) for methyl N-methylanthranilate is 33.3 L/kg, that does not exceed the bioconcentration threshold of 2000. Thus it is concluded that methyl N-methylanthranilate is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.