Registration Dossier

Administrative data

First-aid measures

The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Description of first aid measures

General advice :
First Aid responders should pay attention to self-protection and use the recommended protective clothing
Move out of dangerous area.
Take off contaminated clothing and shoes immediately.
Keep warm and in a quiet place.

If inhaled :
Provide fresh air.
If not breathing, give artificial respiration.
Keep the victim calm and in a semi-upright position.
Call a physician immediately.

In case of skin contact :
Wash off immediately with plenty of water for at least 15 minutes.
Call a physician immediately.

In case of eye contact :
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Call a physician immediately.

If swallowed :
Clean mouth with water and drink afterwards plenty of water.
Never give anything by mouth to an unconscious person.
Do NOT induce vomiting.
Call a physician immediately.

Most important symptoms and effects, both acute and delayed

Symptoms :
headache
Nausea
Vomiting
Tiredness
Dizziness
Unconsciousness

Risks :
If swallowed, severe burns in the oral cavity and throat as well
as danger of perforation of the digestive tract and stomach.

Indication of any immediate medical attention and special treatment needed

Treatment :
Treat symptomatically.
For specialist advice physicians should contact the Poisons
Information Service.

Fire-fighting measures

The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Extinguishing media

Suitable extinguishing media :
Dry extinguishing media based on NaCl or pulverized limestone.

Unsuitable extinguishing media:
Water
Carbon dioxide (CO2)
Alcohol-resistant foam

Special hazards arising from the substance or mixture

Specific hazards during firefighting:
Vapours may form explosive mixture with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.
In contact with water releases flammable gases which may ignite spontaneously.
May form toxic gases on heating or in case of fire.

Advice for firefighters

Special protective equipment for firefighters:

Wear full protective clothing and self-contained breathing apparatus.
Further information : Use water spray to cool unopened containers.
Be aware of a dangerous reaction with water, if the container is ruptured.
Collect contaminated fire extinguishing water separately. This must not be discharged into drains.
Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations.

Accidental release measures

The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Personal precautions, protective equipment and emergency procedures

Personal precautions :
Remove all sources of ignition.
Ensure adequate ventilation.
Wear personal protective equipment.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep people away from and upwind of spill/leak.

Environmental precautions

Environmental precautions :
Do not flush into surface water or sanitary sewer system.
Avoid subsoil penetration.

Methods and materials for containment and cleaning up

Methods for cleaning up :
Never allow contact with water.
Cover spilled material with limestone powder.
Pick up and transfer to properly labelled containers.
Non-sparking tools should be used.
Adequate disposal

Handling and storage

The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Precautions for safe handling

Advice on safe handling :
Use product only in closed system.
Handle under inert gas.
Provide sufficient air exchange and/or exhaust in work rooms.
Provide exhaust ventilation close to floor level.
Never allow water to come into contact with the product.
Wear personal protective equipment.
Handle in accordance with good industrial hygiene and safetypractice.
In general, emissions are controlled and prevented by implementing
an appropriate management system, including regular
informing and training workers.

Advice on protection against fire and explosion:
Vapours may form explosive mixtures with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.
Keep away from sources of ignition - No smoking.
Take precautionary measures against static discharges.
Use explosion-proof equipment.
Uncleaned empty containers can contain product gases,
which form explosive mixtures with air.

Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers:
Keep container tightly closed in a dry and well-ventilated place.
Protect from direct sunlight.
Keep under inert gas.

Advice on common storage :
Never allow product to get in contact with water during storage.
Incompatible with oxidizing agents.
Acids
Storage temperature : -10 - 30 °C

Specific end use(s)

Specific use(s) :
Reagent for organic synthesis., Transported isolated intermediate

Transport information

Land transport (ADR/RID)

UN number:
The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

UN 3399
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE, FLAMMABLE
Methylmagnesium bromide, 2-Methyltetrahydrofurane
Chemical name:
Methylmagnesium bromide in 2-Methyltetrahydrofurane
Class:
4.3 (3)
Classification code:
WF1
Packaging group:
Packing group : I
Hazard Identification Number : X323
Tunnel restriction code : (B/E)
SpecialProvisionsopen allclose all
Shippingopen allclose all
Remarksopen allclose all

Marine transport (IMDG)

UN number:
The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives):

UN 3399
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATERREACTIVE,
FLAMMABLE
Methylmagnesium bromide, 2-Methyltetrahydrofurane
Chemical name:
Methylmagnesium bromide in 2-Methyltetrahydrofurane
Class:
4.3 (3)
Packaging group:
Packing group : I

EmS code:
EmS Code : F-G, S-N
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives):

UN 3399
Proper shipping name and description:
Organometallic substance, liquid, water-reactive, flammable
Methylmagnesium bromide, 2-Methyltetrahydrofurane
Chemical name:
Methylmagnesium bromide in 2-Methyltetrahydrofurane
Class:
4.3 (3)
Packaging group:
494
Remarks
Always transported in solvent, e.g. tetrahydrofuran which has to be named in the proper shipping name and description
SpecialProvisionsopen allclose all

Exposure controls / personal protection

The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).
.

Exposure controls

Engineering measures
Provide sufficient air exchange and/or exhaust in work rooms.
Use product only in closed system.
Provide exhaust ventilation close to floor level.
Take precautionary measures against static discharges.
Electrical equipment should be protected to the appropriate standard.

Personal protective equipment
Respiratory protection : In case of insufficient ventilation wear suitable respiratory
For short-time or low exposures, use breathing apparatus with a filter.

Recommended Filter type:
A-P2
For intensive or prolonged exposure, use a self-contained
breathing apparatus.

Hand protection :
Glove material: Wear suitable gloves.
Protective gloves complying with EN 374.
and

Glove material: Flame retardant gloves
Protective gloves complying with EN 659.
The choice of an appropriate glove does not only depend on its material but also on other quality features and is different from one producer to the other.
The exact break through time can be obtained from the protective glove producer and this has to be observed.
Protective gloves have to be replaced at the first sign of deterioration.

Eye protection :
Eye protection (EN 166)
Tightly fitting safety goggles
Skin and body protection : Flame retardant, antistatic and chemical resistant protective clothing
Hygiene measures : Take off contaminated clothing and shoes immediately.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep away from food, drink and animal feedingstuffs.
Smoking, eating and drinking should be prohibited in the applicationarea.
Wash hands before breaks and at the end of workday.

Protective measures :
Facilities storing or utilizing this material should be equipped with an eyewash facility and safety shower.
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls

General advice :
Do not flush into surface water or sanitary sewer system.
Avoid subsoil penetration.

Stability and reactivity

The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Reactivity

Risk of violent reaction.

Chemical stability

Decomposes on heating., Sensitive to air., Decomposition under influence of moisture is highly accelerated
by heating.

Possibility of hazardous reactions

Hazardous reactions :
Highly flammable liquid and vapour.
In contact with water releases flammable gases which may ignite spontaneously.
May form explosive peroxides.
Reacts violently with water.
Vapours may form explosive mixture with air.

Conditions to avoid

Conditions to avoid :
Keep away from open flames, hot surfaces and sources of ignition.
Keep away from heat.
Strong sunlight for prolonged periods.
Protect from moisture.
Static discharge.
Avoid formation of aerosol.
Avoid contact with air/oxygen.

Incompatible materials

Materials to avoid :
Water
Acids
Oxidizing agents

Hazardous decomposition products

Risk of decomposition. :
Decomposes in contact with water.
Methane

Thermal decomposition :
To avoid thermal decomposition, do not overheat.

Disposal considerations

The following information applies to the substance in 2-Methyl THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Waste treatment methods

Product : Dispose of in accordance with local regulations.

Contaminated packaging : Refer to manufacturer/supplier for information on recovery/recycling.

Waste Code : Waste codes should be assigned by the user, preferably in
discussion with the waste disposal authorities.