Registration Dossier
Registration Dossier
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EC number: 407-770-0 | CAS number: 61597-96-4 D(+)-LACTATE D'ISOBUTYLE
Endpoint summary
Administrative data
Description of key information
The test item ethyl lactate was tested in 25 human volunteers at a concentration of 8 % in petrolatum and produced no sensitisation reactions. By way of read-across, this may be considered as an indication that lactate esters in general, including isobutyl-R-lactate, do not entail a skin sensitisation hazard.
Additional information
No data available for isobutyl-R-lactate. Based on structural similarity, representing lactate esters with alkyl moieties of similar length, available data on ethyl lactate (source substance) was also used in a read-across approach. In the publication by Opdyke et al. (1982) the results of a study performed by Kligman (1976) were referenced. Kligman conducted a maximisation test (Kligman 1966) on 25 human volunteers. The test item ethyl lactate was tested at a concentration of 8 % in petrolatum and produced no sensitisation reactions.
By way of read-across, this may be considered as an indication that lactate esters in general, including isobutyl-R-lactate, do not entail a skin sensitisation hazard.
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