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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
2-[(Hydroxymethyl)amino]ethanol: Reregistration Eligibility Decision (RED) and RED Fact Sheet
Author:
U. S. Environmental Protection Agency (EPA) Office of Pesticide Programs (OPP) Special Review and Reregistration Division (SRRD)
Year:
1993
Bibliographic source:
2-[(Hydroxymethyl)amino]ethanol: Reregistration Eligibility Decision (RED) and RED Fact Sheet, US EPA, 1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of 2-[(Hydroxymethyl)amino]ethanol in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(hydroxymethylamino)ethanol
EC Number:
251-974-0
EC Name:
2-(hydroxymethylamino)ethanol
Cas Number:
34375-28-5
Molecular formula:
C3H9NO2
IUPAC Name:
2-[hydroxy(methyl)amino]ethanol
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 2-(hydroxymethylamino)ethanol
- Molecular formula : C3H9NO2
- Molecular weight :91.11 g/mole
- Substance type: Organic
- Physical state:Liquid
- SMILES: OCCNCO
Specific details on test material used for the study:
Name of test material (as cited in study report): 2-[(Hydroxymethyl)amino] ethanol
Molecular formula: C3H9NO2
Molecular weight: 91.1091 g/mol
Smiles notation: CN(CCO)O
InChI: 1S/C3H9NO2/c14(6)235/h56H,23H2,1H3
Substance Type: Organic
Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100% undiluted test chemical
Duration of treatment / exposure:
single application
Observation period (in vivo):
21 days
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
21 d
Reversibility:
not fully reversible within: 21 days
Remarks on result:
probability of severe irritation
Irritant / corrosive response data:
Severe irritation and corneal opacity was observed which lasted for 21 days

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Severe irritation and corneal opacity was observed which lasted for 21 days when rabbits were exposed to undiluted 2-[(Hydroxymethyl)amino]ethanol.
Hence, 2-[(Hydroxymethyl)amino]ethanol can be considered irritating to rabbit eyes.
Executive summary:

An eye irritation study was carried out in rabbits to assess the irritation potential of2-[(Hydroxymethyl)amino]ethanol.100% (undiluted) 2-[(Hydroxymethyl)amino]ethanol was instilled into the eyes of rabbits and observed for signs of irritation till 21 days. Severe irritation and corneal opacity was observed which lasted for 21 days.

Hence, 2-[(Hydroxymethyl)amino]ethanol can be considered irritating to rabbit eyes.