Registration Dossier
Registration Dossier
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EC number: 206-101-8 | CAS number: 300-92-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report of the Safety Assessment of Lithium Stearate, Aluminum Distearate,Aluminum Stearate, Aluminum Tristearate, Ammonium Stearate, Calcium Stearate, Magnesium Stearate, Potassium Stearate, Sodium Stearate, and Zinc Stearate
- Author:
- SAGE, American College of Toxicology
- Year:
- 1 982
- Bibliographic source:
- International Journal of Toxicology 1982 1: 143
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity test was performed in rats at 100% concentration of aluminum distearate
- GLP compliance:
- no
- Test type:
- other: No data available
Test material
- Reference substance name:
- Hydroxyaluminium distearate
- EC Number:
- 206-101-8
- EC Name:
- Hydroxyaluminium distearate
- Cas Number:
- 300-92-5
- Molecular formula:
- C36H71AlO5
- IUPAC Name:
- hydroxyaluminium distearate
- Details on test material:
- No data available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 100%
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD 50 value for Aluminum distearate (300-92-5) was found to be >5000mg/kg.
- Executive summary:
Acute dermal toxicity test was performed in rats at 100% concentration of aluminum distearate. After experiment it was observed that the LD 50 value for Aluminum distearate (300-92-5) was found to be >5000mg/kg.
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