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EC number: 211-103-7 | CAS number: 629-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 February 1973 to 27 February 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Preparation containing 90 % test item administered to albino rats (five groups of two animals) with 14 day observation period.
- GLP compliance:
- no
- Remarks:
- investigation took place before the introduction of GLP
- Test type:
- other: similar to acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Hexadecyl acetate
- EC Number:
- 211-103-7
- EC Name:
- Hexadecyl acetate
- Cas Number:
- 629-70-9
- Molecular formula:
- C18H36O2
- IUPAC Name:
- hexadecyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Acetulan
- Analytical purity: Declared by owner of study report to contain 90 % test item and to be equivalent to the substance described elsewhere in this dossier
- Lot/batch No.: 615F
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Five groups of albino rats (one male and one female per group) were set aside and observed for a period of one week to assure normalcy.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Animals were starved for 24 hours.
- Doses were determined for each animal and administered directly into the stomach by means of a stomach tube.
- Animals were allowed food and water ad libitum during a fourteen day observation period. - Doses:
- 2.5, 5.0, 10.0, 20.0 and 40.0 mL/kg
- No. of animals per sex per dose:
- One male and one female per dose group
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: no toxicity reported following oral administration
- Mortality:
- No mortality
- Clinical signs:
- other: Not reported
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Any other information on results incl. tables
Dose Level mL/kg |
Number of rats dosed |
Day |
Mortality after 14 days |
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
|||
2.5 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
5.0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
10.0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
20.0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
40.0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was demonstrated to have an acute oral oral LD50 greater than 40.0 mL/kg in the rat.
- Executive summary:
METHOD
A preparation declared to contain 90 % of test item was administered in a single dose by gavage to five groups of Sherman-Wistar rats consisting of one male and one female. Mortality after a fourteen day observation period was reported.
RESULTS
No mortality was observed in rats dosed with 2.5, 5.0, 10.0, 20.0 or 40.0 mL/kg of the test material.
CONCLUSION
The test material was demonstrated to have an acute oral LD50 greater than 40.0 mL/kg in the rat.
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