Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment

The bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (authoritative database, 2017). The bioaccumulation factor (BCF) value was calculated using a logKow of 1.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 8 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Additional information

Bioaccumulation: aquatic / sediment

Various experimental studies for the test chemical were reviewed for the bioaccumulation end point which are summarized as below:

 

In an experimental key study from authoritative database (2017),the bioaccumulation experiment in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 1.85 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 8 dimensionless.

 

Another bioaccumulation study in aquatic organisms was conducted for determining the BCF (bioaccumulation factor) value of test chemical (handbook, 1999). The BCF (bioaccumulation factor) value of test chemical was determined to be 12 dimensionless.

 

In a prediction done using the BCFBAF Program of Estimation Programs Interface was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 7.678 L/kg whole body w.w (at 25 deg C).

 

For the test chemical from authoritative database (HSDB and PubChem, 2017), the bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 1.21 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 1.7 dimensionless.

 

On the basis of above results for test chemical (from handbook, authoritative and modelling databases, 2017), it can be concluded that the BCF value of test chemical was determined upto12 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.