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EC number: 252-046-8 | CAS number: 34455-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Remarks:
- - The study was conducted according to the test guidelines in effect at the time of study conduct.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- Remarks:
- - The study was conducted according to the test guidelines in effect at the time of study conduct.
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- no
- Buffers:
- - pH: pH 4, 7 and 9
- Type and final molarity of buffer:
pH 4: 0.2 M aqueous potassium dihydrogen orthophosphate (110 mL) was mixed with 0.07 M aqueous disodium hydrogen orthophosphate dodecahydrate (250 mL) and purified water (640 mL). The pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid.
pH 7: 0.2 M aqueous potassium dihydrogen orthophosphate (250 mL) was mixed with 1 M sodium hydroxide (30 mL) and purified water (720 mL). The pH was adjusted to 7.0 ± 0.05 with 1 M hydrochloric acid.
pH 9: 0.1 M boric acid in 0.1 M aqueous potassium chloride (500 mL) was mixed with 1 M sodium hydroxide (21 mL) and purified water (480 mL). The pH was adjusted to 9.0 ± 0.05 with 1 M hydrochloric acid. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used:
Aliquots (100 μL) of a stock solution of the test item in methanol (100 g/L) were added to separate Wheaton vials containing buffer solution (10 mL), which had been purged with nitrogen and preequilibrated at test temperature (50 ± 0.5°C). The samples, of nominal concentration 1 g/L, were placed in a 50°C waterbath in the dark until sampling was required (immediately, and then after 2.4 and 120 hours). At each sampling time, two samples were removed from the bath and an aliquot (1 mL) of each was diluted to volume (5 mL) with mobile phase for analysis by high performance liquid chromatography (HPLC). - Duration:
- 120 h
- pH:
- 4
- Initial conc. measured:
- 1 060 mg/L
- Duration:
- 120 h
- pH:
- 7
- Initial conc. measured:
- 1 010 mg/L
- Duration:
- 120 h
- pH:
- 9
- Initial conc. measured:
- 1 000 mg/L
- Number of replicates:
- 1 vessel for each pH, two aliquots were taken for analysis at sampling time
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- The preliminary study showed that at each of pH 4, 7 and 9 and 50 ± 0.5ºC, less than 10% hydrolysis had occurred after 120 hours (5 days), equivalent to a half-life of greater than 1 year under environmental conditions (25°C). No further testing was considered necessary.
- Transformation products:
- no
- % Recovery:
- 97.2
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 112.6
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 103
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes - Validity criteria fulfilled:
- yes
- Conclusions:
- This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
The test item was determined to be hydrolytically stable at pH 4, 7, and 9. - Executive summary:
A study was performed to determine the rate of hydrolysis of the test item as a function of pH. The method followed is amongst those described in Commission Regulation (EC) No. 440/2008 (Method C.7) and the OECD Guidelines for the Testing of Chemicals (Method 111). The test item was exposed to pH 4, 7 and 9 buffers at 50°C for 120 hours. Results showed that the half-life would be greater than a year at 25°C. The test item was determined to be hydrolytically stable under acidic, neutral and basic conditions.
Reference
Description of key information
The test substance is hydrolytically stable under environmental conditions with a half-life of >1 year at 25°C at pH 4, 7, and 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 50 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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