Registration Dossier
Registration Dossier
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EC number: 201-923-3 | CAS number: 89-61-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Determination of LD50 value (Dermal) of chemical 2,5-Dichloronitrobenzene
- Author:
- IFA (GESTIS)
- Year:
- 2 016
- Bibliographic source:
- GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity of chemical 2,5-Dichloronitrobenzene was determined in rats
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 1,4-dichloro-2-nitrobenzene
- EC Number:
- 201-923-3
- EC Name:
- 1,4-dichloro-2-nitrobenzene
- Cas Number:
- 89-61-2
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,4-dichloro-2-nitrobenzene
- Reference substance name:
- 2,5-Dichloronitrobenzene
- IUPAC Name:
- 2,5-Dichloronitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2,5-Dichloronitrobenzene
- Molecular formula (if other than submission substance): C6-H3-Cl2-N-O2
- Molecular weight (if other than submission substance): 192.001
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value was found to be >2000 mg/kg in rats exposed to chemical 2,5-Dichloronitrobenzene in acute dermal test.
- Executive summary:
Acute dermal toxiciyt test was performed to evaluate lethality of chemical 2,5-Dichloronitrobenzene.The animals were exposed by dermal route with dose concentration of 2000 mg/kg.
The animal only showed only a decrease of their spontaneous activity.2000 mg/kg did not lead to any deaths for rats.
The LD50 value was found to be >2000 mg/kg in rats exposed to chemical 2,5-Dichloronitrobenzene in acute dermal test.
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