2-chloro-6,7-dimethoxyquinazolin-4-amine

PBT assessment

PBT assessment: overall result

PBT status:

the substance is not PBT / vPvB

Justification:

Classification of 2-chloro-6,7-dimethoxyquinazolin-4-amine for effects in the environment:

 

The chemical 2-chloro-6,7-dimethoxyquinazolin-4-amine (CAS no. 23680-84-4) is used as pharmaceutical intermediate. The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for 2-chloro-6,7-dimethoxyquinazolin-4-amine. The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.

 

 

Persistence assessment

The tested substance fulfils the P criterion within Annex XIII based on the assessment that here follows:

 

Environmental fate

According to the fugacity model levels III, the most likely environmental fate for this test chemical is soil (i.e.estimated to 89.1%). In soil, 2-chloro-6,7-dimethoxyquinazolin-4-amine was expected to have moderate to slow mobility based upon a Log KOC of 2.18-2.63. The half-life in soil (120 days estimated by EPI suite) indicates that the chemical is not persistent in soil and the exposure risk to soil dwelling animals is moderate to low.

 

If released in to the environment, 10.6 % and 0.279% of the chemical will partition into water and sediment respectively, according to the Mackay fugacity model level III in EPI suite version 4.1 (2016). However, the half-life (60 days in water and 541.66 days in sediment as estimated by EPI suite) indicates that the chemical is persistent in these medium.

Hence it has been concluded that 2-chloro-6,7-dimethoxyquinazolin-4-amine is persistent in nature.  

 

 

Bioaccumulation assessment

The tested substance does not fulfil the B criterion within Annex XIII based on the assessment that here follows:

 

The BCF value is determined as 4.523 at 25ºC (EPI Suite version 4.1, 2015) and the log octanol-water partition coefficient (log Kow) was estimated to 1.5. If this chemical is released into the aquatic environment, there should be a low risk for the chemical to bioaccumulate in fish and food chains.

 

Toxicity assessment

The tested substance does not fulfil the T criterion within Annex XIII based on the assessment that here follows:

 

Mammals

The tested chemical is regarded to be not classified for carcinogenicity, mutagenicity and reprotoxicity, Further, there is no evidence of chronic toxicity, as identified by the classifications STOT (repeated exposure), category 1 (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2 (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume).

 

Aquatic organisms

The predicted EC50/LC50 values were in the range of 185.347 to 555.964 mg/L. Based on these available EC50/LC50 values, 2-chloro-6,7-dimethoxyquinazolin-4-amine was suggested to be classified as ‘non-hazardous’.

 

There are no available long-term toxicity evaluations for 2-chloro-6,7-dimethoxyquinazolin-4-amine. By speculation, since the substance is classified as non-hazardous as per the CLP criterion, classification for aquatic toxicity will not be applicable as per Annex XIII criteria for all of the tropic levels since the minimum LC50 is well above 100 mg/L and the same is based on the above mentioned studies.

 

 

Conclusion

Based on critical, independent and collective evaluation of information summarized herein, the tested compound fulfils the P criterion but does not fulfil the B and T criterion and has therefore not been classified as a PBT compound within Annex XIII.