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EC number: 203-998-8 | CAS number: 112-70-9
The dermal irritation study of the test chemical was conducted on clipped and intact abdominal skin of albino rabbits.
The test chemical was applied full-strength to the closely clipped, intact abdominal skin of albino rabbits in groups of four. The exposed area was covered with an occlusive binding of dental damming for 24 hours. After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin. The animals were housed individually with feed and water freely available. No mechanical restraints were used.
Observations for dermal irritation were made on a daily basis. Gross necropsies were performed at the end of the experiments.Grading scale was slight-moderate-marked and severe.
The findings reveled persistent atonia and desquamation with some necrosis or eschar. Part of the irritation seen was associated with trapping of liquid under the occlusive binder at a point where the binder was bound to the animal. These areas of intimate contact and pressure gave rise to some of the reported necrosis and eschar.Also the chemical showed good dose relations for intensity and duration.
Therefore, the test chemical was considered as moderately irritating to the clipped and intact abdominal skin of albino rabbits.
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