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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicity to the rat
Author:
SCALA et al.
Year:
1973
Bibliographic source:
American Industrial Hygiene Association Journal

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: refer below principle
Principles of method if other than guideline:
Acute Dermal toxicity of test chemical in rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic
Specific details on test material used for the study:
- IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic

Test animals

Species:
rabbit
Strain:
other: Albino
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
Housing: The animals were housed individually
Diet (e.g. ad libitum):ad libitum
Water (e.g. ad libitum): ad libitum

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
- Area of exposure: the closely clipped, intact abdominal skin
- Type of wrap if used: The exposed area was covered with an occlusive binding of dental damming
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin.
- Time after start of exposure:24 hour
Duration of exposure:
24 hours
Doses:
0.10, 0.316, 1.00, and 3.16 ml/kg were administered volumetrically.
No. of animals per sex per dose:
groups of 4 (sex not mentioned)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Observations for signs of toxicity were made frequently on the day of application and once daily afterward for a total of 7 days.
Necropsy of survivors performed: yes/no: Yes, Gross necropsies were performed at the end of the experiments.
Statistics:
The results have been converted to gravimetric expressions by use of the specific gravity.

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 600 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Dose reported is the highest dose tested
Mortality:
No Mortality observed at 2600 mg/kg bw.
Clinical signs:
No signs of toxicity observed
Body weight:
No data
Gross pathology:
No data
Other findings:
On observation of the binders after 24 hours of skin contact, percutaneous absorption was evident with all the alcohols even though the median lethal dose was not achieved.

Any other information on results incl. tables

 

Table: Acute dermal toxicity of alcohols

Alcohol

LD50 (gm/kg)

Signs

Tridecyl

>2.6

None

 

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
Acute dermal toxicity dose (LD50) was considered to be >2600 mg/kg bw, when groups of 4 albino rabbits were treated with test chemical by dermal application occlusively to the closely clipped, intact abdominal skin for 24 hours.
Executive summary:

Acute dermal toxicity study was conducted by using test chemical in groups of 4 albino rabbits at the dose concentration of 0.10, 0.316, 1.00, and 3.16 ml/kg bw administered volumetrically. The animals were housed individually with feed and water freely available. No mechanical restraints were used.The test chemical was applied full-strength to the closely clipped, intact abdominal skin of albino rabbits. The exposed area was covered with an occlusive binding of dental damming for 24 hours. After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin. Observations for signs of toxicity were made frequently on the day of application and once daily afterward for a total of 7 days. Gross necropsies were performed at the end of the experiments. The results have been converted to gravimetric expressions by use of the specific gravity. No Mortality observed at 2600 mg/kg bw. No signs of toxicity observed. On observation of the binders after 24 hours of skin contact, percutaneous absorption was evident with the chemical even though the median lethal dose was not achieved. Therefore, LD50 was considered to be >2600 mg/kg bw, when groups of 4 albino rabbits were treated with test chemical by dermal application occlusively to the closely clipped, intact abdominal skin for 24 hours.