Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicity to the rat
Author:
SCALA et al.
Year:
1973
Bibliographic source:
American Industrial Hygiene Association Journal

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute Inhalation toxicity of the given test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic
- Physical state:White solid
Specific details on test material used for the study:
- IUPAC Name: 1-Tridecanol
- InChI: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Smiles: C(CCCCCCO)CCCCCC
- Molecular formula:C13H28O
- Molecular weight:200.3632 g/mole
- Substance type:Organic
- Physical state:White solid

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified
Details on test animals and environmental conditions:
Housing: group-housed by species during and after the exposures
Diet (e.g. ad libitum):ad libitum, post- exposure
Water (e.g. ad libitum): ad libitum, post-exposure

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
MAXIMUM DOSE VOLUME APPLIED: 12ppm
DOSAGE PREPARATION (if unusual): The exposures were at atmospheres nearly saturated with vapors of the alcohol. The generators were fritted-disk glass bubblers
containing a measured amount of alcohol through which all air entering the chamber was passed.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Remarks on duration:
not specified
Concentrations:
12ppm = 12mg/kg
No. of animals per sex per dose:
Groups of ten rats (sex not mentioned)
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 24 hours
Necropsy of survivors performed: yes/no: Yes, Gross necropsies were performed on the animals that died and at the end of the holding period.
Other examinations performed: Observations were made for mortality, signs of toxic effect, and body weight changes.
Statistics:
Dose reported is calculated from sample loss and airflow

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 12 mg/L air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: No deaths were seen in the 6 hour vapor inhalation studies.
Mortality:
No deaths were seen in the 6 hour vapor inhalation studies.
Clinical signs:
Signs of systemic toxicity were not pronounced and consisted primarily of central nervous system depression. Local irritation was observed to a very less extent in all the test animals. This irritation involved the mucous membranes of the eyes, nose, throat, and respiratory passages and was manifest as blinking, lacrimation, preening, nasal discharge, salivation, gasping, and chewing movements.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Any other information on results incl. tables

 

Table: Acute Toxicity of Alcohol Vapor (6 hour exposure)

 

Alcohol

 

Concentration

Signs

Irritation

Systemic Effects

Tridecyl alcohol

12 ppm

Slight

None

 

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
Acute inhalation toxicity dose (LC50) was considered to be >12 ppm (>12000 mg/m3), when rats were exposed with the given test chemical via inhalation route for 6 hours.
Executive summary:

Acute inhalation toxicity study was conducted by using test chemical in group of 10 Wistar rats at the concentration of 12 ppm for 6 hours of exposure. The exposures were at atmospheres nearly saturated with vapors of the alcohol. The generators were fritted-disk glass bubblers containing a measured amount of alcohol through which all air entering the chamber was passed.Observations were made for mortality, signs of toxic effect, and body weight changes.Gross necropsies were performed on the animals that died and at the end of the holding period.Dose reported is calculated from sample loss and airflow. No deaths were seen in the 6 hour vapor inhalation studies.Signs of systemic toxicity were not pronounced and consisted primarily of central nervous system depression. Local irritation was observed to a very less extent in all the test animals. This irritation involved the mucous membranes of the eyes, nose, throat, and respiratory passages and was manifest as blinking, lacrimation, preening, nasal discharge, salivation, gasping, and chewing movements. Therefore, the acute inhalation toxicity dose (LC50) was considered to be >12 ppm (>12000 mg/m3), when rats were exposed with test chemical via inhalation route for 6 hours.