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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from authoritative database
Justification for type of information:
Data is from authoritative database
Qualifier:
according to
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Principles of method if other than guideline:
Study was assess to evaluate the long term effect of test chemical on the growth and reproduction Inhibition of aquatic invertebrates daphnia magna for the exposure of 21 days. Test conducted according to the OECD Guideline 211 (Daphnia magna Reproduction Test).
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material: Tridecyl alcohol
- IUPAC name: 1-Tridecanol
- Molecular formula: C13H28O
- Molecular weight: 200.37 g/mole
- Smiles notation: C(CCCCCCO)CCCCCC
- InChl: 1S/C13H28O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14/h14H,2-13H2,1H3
- Substance type: Organic
- Physical state: Solid
Analytical monitoring:
not specified
Vehicle:
not specified
Details on test solutions:
Details on test solutions
PREPARATION AND APPLICATION OF TEST SOLUTION:
- Chemical name of vehicle: Dimethylformamide, Hydrogenated castor oil (HCO-40)
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 100 microL/L [ mixed solution of Dimethylformamide / Hydrogenated castor oil (HCO-40) = 3/1 (w/w) ]
Test organisms (species):
Daphnia magna
Details on test organisms:
Details on test organisms
TEST ORGANISM
- Common name: Water flea
Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
21 d
Test temperature:
24 ± 1° C
Nominal and measured concentrations:
control, vehicle control, 0.022, 0.046, 0.10, 0.22, 0.46 mg/L (geometric ratio: 2.2)
Details on test conditions:
Details on test conditions
TEST SYSTEM
- Material, size, headspace, fill volume: Test solution volume 80 mL per vessel
- Renewal rate of test solution (frequency/flow rate): Total amount of the test solution was renewed every 24 hours
- No. of organisms per vessel: 10 per concentration (1 per vessel)
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
- No. of vessels per vehicle control (replicates): 10

OTHER TEST CONDITIONS:
- Photoperiod: 16 hours light / 8 hours dark
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
0.46 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: Other details not known
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.22 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: Other details not known

- 50 % Lethal concentration (LC50) to parental Daphnia (21 d): > 0.46 mg/L

- Lowest observed effect concentration (LOEC) for reproduction (21 d): 0.46 mg/L

Validity criteria fulfilled:
not specified
Conclusions:
After the exposure of test chemical with the aquatic invertebrates daphnia magna for 21 days, effect concentration EC50 was determine to be 0.46 mg/l and the NOEC was 0.22 mg/l.
Executive summary:

Study was assess to evaluate the long term effect of test chemical on the growth and reproduction Inhibition of aquatic invertebrates daphnia magna for the exposure of 21 days. Test conducted according to the OECD Guideline 211 (Daphnia magna Reproduction Test). 100 microL/L [mixed solution of Dimethylformamide / Hydrogenated castor oil (HCO-40) = 3/1 (w/w)] used as a vehicle. Test conducted under the Semi-static method at different concentrations control, vehicle control, 0.022, 0.046, 0.10, 0.22, 0.46 mg/L (geometric ratio: 2.2). 80 ml/vessel test solution added with the total amount of the test solution was renewed every 24 hours. 1 test organism added in each vessel and performed in the 10 replicates. After the exposure of test chemical with the aquatic invertebrates daphnia magna for 21 days, effect concentration EC50 was determine to be 0.46 mg/l and the NOEC was 0.22 mg/l. Based on the EC50 chemical was consider as toxic and can be consider to be classified as aquatic chronic 3 category as per the CLP classification criteria.The test substance is redialy biodegradable in aquatic environment and hence , based on that we can consider that the test substance is not classified as per CLP criteria.

Description of key information

Study was assess to evaluate the long term effect of test chemical on the growth and reproduction Inhibition of aquatic invertebrates daphnia magna for the exposure of 21 days. Test conducted according to the OECD Guideline 211 (Daphnia magna Reproduction Test). 100 microL/L [mixed solution of Dimethylformamide / Hydrogenated castor oil (HCO-40) = 3/1 (w/w)] used as a vehicle. Test conducted under the Semi-static method at different concentrations control, vehicle control, 0.022, 0.046, 0.10, 0.22, 0.46 mg/L (geometric ratio: 2.2). 80 ml/vessel test solution added with the total amount of the test solution was renewed every 24 hours. 1 test organism added in each vessel and performed in the 10 replicates. After the exposure of test chemical with the aquatic invertebrates daphnia magna for 21 days, effect concentration EC50 was determine to be 0.46 mg/l and the NOEC was 0.22 mg/l. Based on the EC50 chemical was consider as toxic and can be consider to be classified as aquatic chronic 3 category as per the CLP classification criteria.The test substance is redialy biodegradable in aquatic environment and hence , based on that we can consider that the test substance is not classified as per CLP criteria.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.22 mg/L

Additional information

Study was assess to evaluate the long term effect of test chemical on the growth and reproduction Inhibition of aquatic invertebrates daphnia magna for the exposure of 21 days. Test conducted according to the OECD Guideline 211 (Daphnia magna Reproduction Test). 100 microL/L [mixed solution of Dimethylformamide / Hydrogenated castor oil (HCO-40) = 3/1 (w/w)] used as a vehicle. Test conducted under the Semi-static method at different concentrations control, vehicle control, 0.022, 0.046, 0.10, 0.22, 0.46 mg/L (geometric ratio: 2.2). 80 ml/vessel test solution added with the total amount of the test solution was renewed every 24 hours. 1 test organism added in each vessel and performed in the 10 replicates. After the exposure of test chemical with the aquatic invertebrates daphnia magna for 21 days, effect concentration EC50 was determine to be 0.46 mg/l and the NOEC was 0.22 mg/l. Based on the EC50 chemical was consider as toxic and can be consider to be classified as aquatic chronic 3 category as per the CLP classification criteria.The test substance is redialy biodegradable in aquatic environment and hence , based on that we can consider that the test substance is not classified as per CLP criteria.