Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract available only.

Data source

Reference
Reference Type:
publication
Title:
Initial submission: Letter from Rohm & Haas to USEPA: Toxicity studies of triphenylphosphine and triphenylphosphine oxide with attachments & cover letter dated 092292
Author:
Rohm & Haas Co
Year:
1992
Bibliographic source:
U.S.E.P.A., TSCATS OTS0570648, New Doc.I.D. 88-920008034

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Triphenylphosphine oxide
Purity: not reported

Test animals

Species:
dog
Strain:
Beagle
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
4 weeks
Frequency of treatment:
6 h/day, 5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
10.5 and 78.5 mg/m3
Basis:

No. of animals per sex per dose:
2
Control animals:
other: yes, isopropanol
Details on study design:
Post-exposure period: 4 weeks

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
78.5 mg/m³ air
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: no effects observed

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

There were no signs of reaction to the treatment such as
neuromuscular incoordination or impairment during or after
the exposure.
The pathology report on tissue evaluation revealed no pattern of gross lesions or abnormalities.

Applicant's summary and conclusion