Registration Dossier
Registration Dossier
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EC number: 200-911-5 | CAS number: 75-87-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity for CAS no: 75-87-6
- Author:
- European Chemicals Bureau (ECB)
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset, European Chemicals Bureau (ECB), 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 2, 2, 2-trichloroacetaldehyde was performed in guinea pig .
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Trichloroacetaldehyde
- EC Number:
- 200-911-5
- EC Name:
- Trichloroacetaldehyde
- Cas Number:
- 75-87-6
- Molecular formula:
- C2HCl3O
- IUPAC Name:
- 2,2,2-trichloroacetaldehyde
- Details on test material:
- Name of test material (as cited in study report):2, 2, 2-trichloroacetaldehyde
- Molecular formula :C2HCI3O
- Molecular weight :147.387 g/mole
- Substance type:organic
- Physical state:Liquid
Purity:No data available
- Impurities (identity and concentrations):No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):2, 2, 2-trichloroacetaldehyde
- Molecular formula :C2HCI3O
- Molecular weight :147.387 g/mole
- Substance type:organic
- Physical state:Liquid
Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 1510-15000 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 510 - 15 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: No classified
- Conclusions:
- LD50 was considered in range of 1510-15000 mg/kg body weight, when guinea pigs were treated with the given test chemical by dermal application.
- Executive summary:
Acute dermal toxicity study was done in guinea pigs using test material.50% mortality observed at dose range 1510-15000 mg/kg ,hence, LD50 was considered to be1510-15000mg/kg body weight. When guinea pigs were treated with test chemical by dermal application.
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