Registration Dossier
Registration Dossier
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EC number: 200-911-5 | CAS number: 75-87-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity for 75-87-6
- Author:
- REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
- Year:
- 2 017
- Bibliographic source:
- REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS),2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- Acute oral toxicity study of the given test chemical was performed in Rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Trichloroacetaldehyde
- EC Number:
- 200-911-5
- EC Name:
- Trichloroacetaldehyde
- Cas Number:
- 75-87-6
- Molecular formula:
- C2HCl3O
- IUPAC Name:
- 2,2,2-trichloroacetaldehyde
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Chloral
- Molecular formula: C2HCl3O
- Molecular weight: 147.3879 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C=O)(Cl)(Cl)Cl
- InChl: 1S/C2HCl3O/c3-2(4,5)1-6/h1H
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 850 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 850 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality was observed at 850 mg/kg bw.
- Clinical signs:
- other: Somnolence (general depressed activity); Ataxia and Alteration of classical conditioning were observed in treated rats.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 value was considered to be 850 mg/kg body weight, when rats were treated with the given test chemical orally.
- Executive summary:
Acute oral toxicity study was done in rat using test material at dose concentration of 850 mg/kg bw. Animals were observed for mortality and signs of toxicity. 50% mortality observed at dose 850 mg/kg bw. Clinical signs like Somnolence (general depressed activity); Ataxia and Alteration of classical condition were observed. Hence, the acute oral LD50 value was considered to be 850 mg/kg body weight, when rats were treated with the given test chemical orally.
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