Trichloroacetaldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary source.

Data source

Reference

Reference Type:

secondary source

Title:

Acute oral toxicity for 75-87-6

Author:

REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)

Year:

2017

Bibliographic source:

REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS),2017

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mention below

Principles of method if other than guideline:

Acute oral toxicity study of the given test chemical was performed in Rat.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trichloroacetaldehyde

EC Number:

200-911-5

EC Name:

Trichloroacetaldehyde

Cas Number:

75-87-6

Molecular formula:

C2HCl3O

IUPAC Name:

2,2,2-trichloroacetaldehyde

Test material form:

liquid

Details on test material:

- Name of test material (as cited in study report): Chloral
- Molecular formula: C2HCl3O
- Molecular weight: 147.3879 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C=O)(Cl)(Cl)Cl
- InChl: 1S/C2HCl3O/c3-2(4,5)1-6/h1H

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

850 mg/kg

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

850 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality observed

Mortality:

50% mortality was observed at 850 mg/kg bw.

Clinical signs:

other: Somnolence (general depressed activity); Ataxia and Alteration of classical conditioning were observed in treated rats.

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The acute oral LD50 value was considered to be 850 mg/kg body weight, when rats were treated with the given test chemical orally.

Executive summary:

Acute oral toxicity study was done in rat using test material at dose concentration of 850 mg/kg bw. Animals were observed for mortality and signs of toxicity. 50% mortality observed at dose 850 mg/kg bw. Clinical signs like Somnolence (general depressed activity); Ataxia and Alteration of classical condition were observed. Hence, the acute oral LD50 value was considered to be 850 mg/kg body weight, when rats were treated with the given test chemical orally.