Trichloroacetaldehyde

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

ECOSAR estimates log Kow values using the US EPA's KOWWIN Program for aquatic toxicity.Toxicity of a chemical was measured on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program based upon the octanol /water partition coefficient (Kow). Data from ECOSAR class,neutral organics was used.

The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. The intended application domain of EPI Suite is organic chemicals, and inorganic as well as organometallic chemicals generally can be considered outside the domain.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Reference substance (positive control):

no

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

340.8 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: Neutral Organics, Note: * = asterisk designates: Chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to Daphnid (aquatic invertebrates) was predicted to be 340.80 mg/l for test chemical in 48 hrs. Based on this value it can be concluded that the test chemical is likely to be non toxic to aquatic environment and can be considered to be not classified as per the criteria mentioned in CLP regulation.

Executive summary:

Using the EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 340.80 mg/l for test chemical in 48 h. Based on this value it can be concluded that the substance is likely to be non toxic to aquatic environment and can be considered to be not classified as per the criteria mentioned in CLP regulation.

Description of key information

Using the EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 340.80 mg/l for test chemical in 48 h. Based on this value it can be concluded that the substance is likely to be non toxic to aquatic environment and can be considered to be not classified as per the criteria mentioned in CLP regulation.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

340.8 mg/L

Additional information

Four studies including predicted data from validated tools and experimental data from authoritative database of test chemical and its structurally similar read across are reviewed for short term toxicity aquatic invertebrate and their results are summarized below

 

In first study by using the EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 340.80 mg/l for test chemical in 48 h. Based on this value it can be concluded that the substance is likely to be non toxic to aquatic environment and can be considered to be not classified as per the criteria mentioned in CLP regulation.

 

In another study based on the QSAR prediction done using the Danish (Q)SAR Database, the 48 hours effect concentration i.e EC50 of test chemical was estimated to be 345.183 mg/l on Daphnia Magna for with immobilization effects. Thus based on predicted effect value it can be concluded that the test chemical is not classified as per the criteria of CLP regulation.

 

In next study short term toxicity of test chemical to aquatic invertebrate was determined by performing the experiment for 24 h using test guideline DIN 38412 Teil 11, the test organism used in the study was Daphnia magna. The EC0, EC50 and EC100 value of test chemical was determined to be 13 mg/L, 556 – 714 mg/L and 1000 mg/L after the exposure of test chemical to Daphnia magna for 24 h.

 

In last study the short term toxicity of test chemical to aquatic invertebrate was determined by performing the experiment for 24 h using test guideline OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) , the test organism used in the study was Daphnia magna. The effect concentration EC50 value of test chemical was determined to be >98 mg/L on the basis of immobilization effect after the exposure of test chemical to Daphnia magna for 48 h.

 

By considering the results of all the studies mentioned above it is concluded that EC50 value of test chemical is in range of >98 mg/L to 714 mg/L. On the basis of this range EC50 value the test chemical it is considered nonhazardous to aquatic invetebrates cannot classified as per the CLP classification criteria.