Trichloroacetaldehyde

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Environmental Bioconcentration for test chemical was determined using a log Kow of 1.2 and a regression-derived equation.

GLP compliance:

no

Radiolabelling:

no

Vehicle:

not specified

Test organisms (species):

other: Fish

Route of exposure:

aqueous

Test type:

not specified

Water / sediment media type:

not specified

Reference substance (positive control):

not specified

Details on estimation of bioconcentration:

BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 1.2

Key result

Type:

BCF

Value:

5

Basis:

whole body w.w.

Calculation basis:

other: regression derived equation

Remarks on result:

other: Other details not known

According to a classification scheme the BCF (BCF = 5.0) suggests the potential for bioconcentration in aquatic organisms is low.

Validity criteria fulfilled:

not specified

Conclusions:

The BCF (bioaccumulation factor) of test chemical was determined to be 5 dimensionless calculated using a log Kow of 1.2 and a regression-derived equation.

Executive summary:

The bioaccumulation study was conducted on fish for determining the BCF (bioaccumulation factor) value of test chemical. The BCF (bioaccumulation factor) was calculated using a log Kow of 1.2 and a regression-derived equation. The BCF (bioaccumulation factor) of test chemical was determined to be 5 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is non-bioaccumulative in aquatic organisms.

Description of key information

The bioaccumulation study was conducted on fish for determining the BCF (bioaccumulation factor) value of test chemical. The BCF (bioaccumulation factor) was calculated using a log Kow of 1.2 and a regression-derived equation. The BCF (bioaccumulation factor) of test chemical was determined to be 5 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is non-bioaccumulative in aquatic organisms.

Key value for chemical safety assessment

BCF (aquatic species):

5 dimensionless

Additional information

Various experimental study and predicted data for the test chemical and its structurally similar read across chemical were reviewed for the bioaccumulation end point which are summarized as below:

 

The first bioaccumulation study was conducted on fish for determining the BCF (bioaccumulation factor) value of test chemical. The BCF (bioaccumulation factor) was calculated using a log Kow of 1.2 and a regression-derived equation. The BCF (bioaccumulation factor) of test chemical was determined to be 5 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is non-bioaccumulative in aquatic organisms.

 

In another study the BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2020) program was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w at 25 °C which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is non-bioaccumulative in nature.

 

In next study using Bio-concentration Factor (v12.1.0.50374) module, the BCF over the entire pH scale (pH 0 - 14) of the test chemical was estimated to be 9.85 (log BCF = 1.0 ± 1.0). This value indicates that the test chemical was considered to be non-bioaccumulative in aquatic organisms.

 

In last bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 0.99 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.

 

On the basis of above results for test chemical, it is concluded that the BCF value of test chemical ranges from 3.162 – 9.85 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is not expected to bioaccumulate in the food chain.