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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database
Qualifier:
according to guideline
Guideline:
other: Refer principle below
Principles of method if other than guideline:
The Hydrolysis of test chemical was determined
GLP compliance:
not specified
Radiolabelling:
no
Analytical monitoring:
not specified
Transformation products:
yes
No.:
#1
Remarks on result:
other: very little test chemical recovered
Remarks on result:
other: 3.6X10-5 equilibrium constant
Validity criteria fulfilled:
not specified
Conclusions:
Test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis od equilibrium constant value very little test chemical is recovered.
Executive summary:

Test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis od equilibrium constant value very little test chemical is recovered.

Description of key information

Test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis od equilibrium constant value very little test chemical is recovered.

Key value for chemical safety assessment

Additional information

Different studies were performed to determine the hydrolysis rate constant and half-life of test chemical and its structurally similar read across chemicals and results are summarized below

 

In first study from authoritative database the test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis of equilibrium constant value very little test chemical is recovered.

 

Another study was conducted to determine the half-life of hydrolysis of test chemical by using different buffers namely MOPS and carbonates. The half-life of hydrolysis of test chemical was determined to be 9 days and 15 days with hydrolysis rate constant of 1.1E-3/h and 1.8E-3/h respectively. On the basis of half-life values test chemical is considered to be hydrolysable.

 

By considering results of both the studies test chemical is considered to be hydrolysable.