2,3-xylenol

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authorative database

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

Environmental Bioconcentration of test chemical was determine using an estimated log Kow of 2.61 and a regression derived equation.

GLP compliance:

not specified

Radiolabelling:

not specified

Vehicle:

not specified

Test organisms (species):

other: fish

Route of exposure:

aqueous

Test type:

not specified

Water / sediment media type:

natural water: freshwater

Reference substance (positive control):

not specified

Key result

Type:

BCF

Value:

57 dimensionless

Basis:

whole body w.w.

Calculation basis:

other: regression-derived equation

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

From authorative database HSDB an estimated BCF of 57 was calculated for test chemical using an estimated log Kow of 2.61 and a regression derived equation.

Executive summary:

From authorative database HSDB, an estimated BCF of 57 was calculated for test chemical, using an estimated log Kow of 2.61and a regression derived equation.This BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

Description of key information

From authorative database HSDB, an estimated BCF of 57 was calculated for test chemical, using an estimated log Kow of 2.61and a regression derived equation.This BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

Key value for chemical safety assessment

BCF (aquatic species):

57 dimensionless

Additional information

Experimental study and predicted data of the target chemical were reviewed for the bioaccumulation end point which are summarized as below:

 

In an experimental study from authoritative database, an estimated BCF of 57 was calculated for test chemical, using an estimated log Kow of 2.61and a regression derived equation.

 

In a prediction done using the BCFBAF (v3.00) model of EPI suite, the estimated bio concentration factor (BCF) for test chemical is 20.1 L/kg wet-wt.

 

From Scifinder database, the bioconcentration factor (BCF) for target chemical was predicted to be 38.0 at pH range 1-8, 36.6 at pH 9 and 27.6 at pH 10 at temperature 25 deg.C.

 

Using the Chemspider - ACD/PhysChem Suite prediction model the Bioconcentration factor (BCF) for target chemical was estimated to be 36.5 at pH 5.5 and 7.4 at temperature 25°C.

 

On the basis of above results, it can be concluded that the BCF value of test chemical was evaluated to be ranges from 20.1 to 57, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.