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Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment

From authorative database HSDB, a BCF of 57 was calculated for 2,3dimethylphenol, using an estimated log Kow of 2.61and a regression derived equation.This BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

Additional information

Bioaccumulation: aquatic / sediment

Four studies including experimental data from authorative database and predicted data from validated models for bioaccumulation (BCF) endpoint of target chemical 2,3-dimethylphenol (Cas no. 526-75-0) were summarized as follows:  

 

First study from experimental data for target chemical (Cas no. 526-75 -0) which suggest a BCF of 57 was calculated for 2,3 dimethylphenol, using an estimated log Kow of 2.61and a regression derived equation. This BCF suggests the potential for bioconcentration in aquatic organisms is moderate. (HSDB database by US EPA; 2017)

 

Above experimental result supported by prediction using BCFBAF (v3.00) model and PBT profiler which indicate the estimated bio concentration factor (BCF) for 2,3dimethylphenol is 20.1 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 2,3-dimethylphenol is not expected to bio accumulate in the aquatic environment.

 

Above prediction is further assisted by Scifinder database wherein the Bioconcentration factor (BCF) for target chemical 2,3-dimethylphenol was predicted to be 38.0 at pH range 1-8, 36.6 at pH 9 and 27.6 at pH 10 at temperature 25 deg.C. Based on the BCF concentration at all range of pH it is concluded that the test chemical 2,3-dimethylphenol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

 

And data from Chemspider - ACD/PhysChem Suite prediction model also indicate the Bioconcentration factor (BCF) for target chemical 2,3-dimethylphenol was to be estimated as 36.56 at pH 5.5 and 7.4 at temperature 25 deg.C. Based on the BCF concentration at two different pH concluded that the test chemical 2,3-dimethylphenol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

 

Thus based on all available studies for bioaccumulation endpoint concluded that the test substance 2, 3-dimethylphenol (Cas no. 526-75-0) is expected to be non Bioaccumulative in aquatic environment.