Registration Dossier
Registration Dossier
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EC number: 214-901-3 | CAS number: 1208-67-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety Assessment of Various Aryl alkyl hydratropes used in Cosmetics
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 2 011
- Bibliographic source:
- International Journal of Toxicology, 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- An eye irritation study was performed to assess the ocular irritation potential of the test chemical in rabbits according to OECD 405 Guidelines.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium cumenesulphonate
- EC Number:
- 248-983-7
- EC Name:
- Sodium cumenesulphonate
- Cas Number:
- 28348-53-0
- Molecular formula:
- C9H12O3S.Na
- IUPAC Name:
- sodium 2-phenylpropane-2-sulfonate
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Sodium cumenesulphonate
Molecular Weight: 223.2468 g/mol
Molecular Formula:C9H12O3S.Na
Substance Type: Organic
SMILES Notation :c1(ccccc1)S(=O)(=O)[O-].[Na+].CC([*])C
Physical State: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Duration of post- treatment incubation (in vitro):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation were observed in treated rabbits.
Any other information on results incl. tables
Table: Results of eye irritation studies
CAS |
Exposure details |
Method |
Irritation endpoints |
28348-53-0 |
Not specified |
OECD 405 |
No signs of irritation were observed in rabbits eyes |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No signs of irritation were observed in treated rabbits. Hence, the test chemical was considered to be not irritating to rabbit eyes.
- Executive summary:
An ocular irritation study in rabbits was performed to assess the irritation potential of the test chemical.The test was performed in accordance with OECD 405 Guidelines.
Undiluted test chemical instilled in to the rabbit eyes and effects were observed (dose and duration not specified)
No signs of irritation were observed in treated rabbits. Hence, the test chemical was considered to be not irritating to rabbit eyes.
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