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Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Safety Assessment of the given test chemical
Author:
Bergfeld et al.
Year:
2011
Bibliographic source:
International Journal of Toxicology
Reference Type:
secondary source
Title:
SIDS Initial Assessment Report
Author:
United Nations Environmental Programme (UNEP)
Year:
2005
Bibliographic source:
United Nations Environmental Programme (UNEP) 2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity of the given test chemical in rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium cumenesulphonate
EC Number:
248-983-7
EC Name:
Sodium cumenesulphonate
Cas Number:
28348-53-0
Molecular formula:
C9H12O3S.Na
IUPAC Name:
sodium 2-phenylpropane-2-sulfonate
Details on test material:
- IUPAC Name: Sodium cumenesulphonate
- Smiles : c1(ccccc1)S(=O)(=O)[O-].[Na+].CC([*])C
- Molecular formula :C9H12O3S.Na
- Molecular weight: 223.2468 g/mole
- Substance type:Organic
- Physical state:Solid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed at 2000 mg/kg bw in treated animals.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute dermal toxicity dose (LD50) value was considered to be >2000 mg/kg bw, when rabbits were treated with the given test chemical by dermal application.
Executive summary:

Acute dermal toxicity study was conducted using the given test chemical in rabbits at the dose concentration of 2000 mg/kg bw.

Animals were observed for mortality. No mortality was observed at 2000 mg/kg bw in treated animals.

Hence, the LD50 value was considered to be >2000 mg/kg bw, when rabbits were treated with the given test chemical by dermal application.