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Registration Dossier
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EC number: 226-999-5 | CAS number: 5590-18-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- Acute inhalation toxicity of test chemical
- Author:
- Jay A. Brown
- Year:
- 2 017
- Bibliographic source:
- Haz-Map: Information on Hazardous Chemicals and Occupational Diseases, 2017.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study for the given test chemical in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- EC Number:
- 226-999-5
- EC Name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- Cas Number:
- 5590-18-1
- Molecular formula:
- C22H6Cl8N4O2
- IUPAC Name:
- 3,3'-(1,4-phenylenediimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
- Details on test material:
- - IUPAC Name: 3,3'-(1,4-phenylenediimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
- Common Name: C.I. Pigment Yellow 110
- InChI: 1S/C22H6Cl8N4O2/c23-11-7-9(13(25)17(29)15(11)27)21(35)33-19(7)31-5-1-2-6(4-3-5)32-20-8-10(22(36)34-20)14(26)18(30)16(28) 12(8)24/h1-4H,(H,31,33,35)(H,32,34,36)
- Smiles: C=1(c2c(c(c(Cl)c(Cl)c2C(=O)N1)Cl)Cl)Nc1ccc(cc1)NC1=NC(c2c1c(c(c(c2Cl)Cl)Cl)Cl)=O
- Molecular formula:C22H6Cl8N4O2
- Molecular weight:641.939 g/mole
- Substance type:Organic
- Physical state:Yellow odorless powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- not specified
- Concentrations:
- 1000 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 1 000 mg/m³ air
- Based on:
- test mat.
- Mortality:
- No mortality was observed
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation toxicity study in rat by using the test chemical was considered to be >1000 mg/m3.
- Executive summary:
The acute inhalation toxicity study was conducted by using the given test chemical in rats at the concentration of 1000 mg/m3. No mortality was observed at 1000 mg/m3.
Therefore, the LC50 was considered to be >1000 mg/m3, when rats were treated with test chemical by inhalation.
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