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EC number: 204-504-3 | CAS number: 121-89-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from U.S Environmental protection Agency report
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Investigation of selected Potential environmental contaminants: Nitroaromatics
- Author:
- Philip H. Howard, Joseph Santodonato, Jitendra Saxna, Judith Malling and Dorothy Greninger
- Year:
- 1 976
- Bibliographic source:
- U.S Environmental protection Agency, June 1976, page no 372
- Reference Type:
- secondary source
- Title:
- Acute Oral Toxicity of 3'-Nitroacetophenone
- Author:
- German Federal Ministry for the Environment
- Year:
- 2 016
- Bibliographic source:
- GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States, 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity of 3'-Nitroacetophenone in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 3'-nitroacetophenone
- EC Number:
- 204-504-3
- EC Name:
- 3'-nitroacetophenone
- Cas Number:
- 121-89-1
- Molecular formula:
- C8H7NO3
- IUPAC Name:
- 3'-nitroacetophenone
- Reference substance name:
- 3-nitroacetophenone
- IUPAC Name:
- 3-nitroacetophenone
- Test material form:
- solid
- Details on test material:
- Name of test material (as cited in study report): 3 nitro acetophenone
Molecular formula : C8H7NO3
Molecular weight: 165.147 g/mol
Smiles notation : c1(cc(ccc1)[N+](=O)[O])C(C)=O
InChl : 1S/C8H7NO3/c16(10)73248(57)9(11)12/h25H,1H3
Substance type: Organic
Physical state: Solid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3'-Nitroacetophenone
- Molecular formula (if other than submission substance): C8H7NO3
- Molecular weight (if other than submission substance): 165 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- other: Carworth Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: 90 -120g
Fasting period before study: No fasting
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
Concentration in vehicle: 3250 mg/kg
Amount of vehicle (if gavage): 1 ml to 10 ml
CLASS METHOD (if applicable)
Rationale for the selection of the starting dose:
Doses were given in a logarithmic series differing by a factor of 2. - Doses:
- 3250 mg/kg bw
- No. of animals per sex per dose:
- 5 male
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- The most probable LD50 value and its fiducial range are estimated by the method of Thompson, using the Tables of Weil. The figures in parentheses show limits of ± 1.96 standard deviations while the absence of parentheses indicates that no range is calculable because no dosage resulted in fractional mortality
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 250 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed.
- Mortality:
- 50 % mortality was observed in treated rats at 3250 mg/kg bw after 14 days
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 3250 mg/kg bw when Carworth Wistar male rat were treated with 3'-Nitroacetophenone orally by gavage
- Executive summary:
In a Acute oral toxicity study, 5 Carworth Wistar male rats were treated with 3'-Nitroacetophenone in the concentration of 3250 mg/kg bw orally by gavage and observed for 14 days. 50 % mortality was observed in treated rats at 3250 mg/kg bw after 14 days. Therefore, LD50 was considered to be 3250 mg/kg bw when Carworth Wistar male rat were treated with 3'-Nitroacetophenone orally by gavage.
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