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EC number: 204-320-3 | CAS number: 119-40-4
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from PBT Profiler and EPI Suite modelling database
Data source
Referenceopen allclose all
- Reference Type:
- other: Prediction model
- Title:
- Biodegradation in soil by Environmental Science Center’s PBT profiler
- Author:
- Environmental Science Center
- Year:
- 2 017
- Bibliographic source:
- PBT profiler, Office of Chemical Safety and Pollution Prevention , U.S. Environmental Protection Agency; version 1.301
- Reference Type:
- other: Prediction model
- Title:
- Biodegradation in soil by EPI (Estimation Programs Interface) Suite
- Author:
- Sustainability Support Service (Europe) AB - estimated
- Year:
- 2 011
- Bibliographic source:
- Estimation Programs Interface Suite™ United States Environmental Protection Agency, Washington, DC, USA. version 4.1
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- PBT profiler database & EPI Suite estimation database.
- GLP compliance:
- no
Test material
- Reference substance name:
- 7-anilino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 204-320-3
- EC Name:
- 7-anilino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 119-40-4
- Molecular formula:
- C16H13NO4S
- IUPAC Name:
- 7-anilino-4-hydroxynaphthalene-2-sulfonic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid- Molecular formula: C16H13NO4S- Molecular weight: 315.35 g/mOl- Smiles notation: c1ccc(cc1)Nc2ccc3c(c2)cc(cc3O)S(=O)(=O)O- Substance type: Organic- Physical state: Solid
Constituent 1
- Radiolabelling:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Fish
Study design
- Route of exposure:
- aqueous
- Test type:
- other: estimated
- Water / sediment media type:
- not specified
Test conditions
- Reference substance (positive control):
- not specified
Results and discussion
Bioaccumulation factor
- Type:
- BCF
- Value:
- 3.2 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: estimated
Any other information on results incl. tables
BCFBAF Program (v3.01) Results:
==============================
SMILES : O=S(=O)(O)c(cc(O)c(c1cc(Nc(cccc2)c2)c3)c3)c1
CHEM : 2-Naphthalenesulfonic acid, 4-hydroxy-7-(phenylamino)-
MOL FOR: C16 H13 N1 O4 S1 MOL WT : 315.35
--------------------------------- BCFBAF v3.01 --------------------------------
Summary Results: Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 0.0121 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 0.05 (BAF = 1.12 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 0.83
Equation Used to Make BCF estimate:
Log BCF = 0.50 (Ionic; Log Kow dependent)
Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt)
Applicant's summary and conclusion
- Conclusions:
- Bioaccumulation concentration factor (BCF) for 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
- Executive summary:
Bioaccumulation is the process by which the chemical concentration in an aquatic organism achieves a level that exceeds that in the water, as a result of chemical uptake through all possible routes of exposure. The relationship between bioaccumulation and bio-concentration is that, chemicals that have the potential to bioconcentrate also have the potential to bioaccumulate. Bioaccumulation is closely related to the Bioconcentration factor (BCF).
Bioaccumulation concentration factor (BCF) for 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid is not expected to bioaccumulate in the food chain because it does not exceed the BCF criteria.
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